ID   CM36_CONPL              Reviewed;          58 AA.
AC   P0CH21;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Conotoxin Pu3.6;
DE   Flags: Precursor; Fragment;
OS   Conus pulicarius (Flea-bitten cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=93154;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=20307606; DOI=10.1016/j.peptides.2010.03.010;
RA   Wu X.-C., Zhou M., Peng C., Shao X.-X., Guo Z.-Y., Chi C.-W.;
RT   "Novel conopeptides in a form of disulfide-crosslinked dimer.";
RL   Peptides 31:1001-1006(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:20307606}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       1 branch, since 1 residue stands between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CH21; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          <1..12
FT                   /evidence="ECO:0000255"
FT   PROPEP          13..41
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000397194"
FT   PEPTIDE         44..58
FT                   /note="Conotoxin Pu3.6"
FT                   /id="PRO_0000397195"
FT   DISULFID        44..56
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        45..54
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        50..57
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   NON_TER         1
SQ   SEQUENCE   58 AA;  6646 MW;  2CB08BE70DB36B2F CRC64;
     VLFPLATLQL DADQPVERYA ENKQDLNPDE RMKFILHALG QRRCCISPAC NDSCYCCQ