CM37_CONRE
ID CM37_CONRE Reviewed; 62 AA.
AC A0A2I6EDL7;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 1.
DT 25-MAY-2022, entry version 12.
DE RecName: Full=Conotoxin reg3.7 {ECO:0000303|PubMed:29283511};
DE Short=Rg3.7 {ECO:0000312|EMBL:AUJ88065.1};
DE Flags: Precursor; Fragment;
OS Conus regius (Crown cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX NCBI_TaxID=101314;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=29283511; DOI=10.1111/febs.14372;
RA Franco A., Dovell S., Moller C., Grandal M., Clark E., Mari F.;
RT "Structural plasticity of Mini-M conotoxins: expression of all mini-M
RT subtypes by Conus regius.";
RL FEBS J. 285:887-902(2017).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29283511}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:29283511}.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC 1 branch, since 1 residue stands between the fourth and the fifth
CC cysteine residues. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MF588941; AUJ88065.1; -; mRNA.
DR AlphaFoldDB; A0A2I6EDL7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Disulfide bond; Secreted;
KW Signal; Toxin.
FT SIGNAL <1..15
FT /evidence="ECO:0000305"
FT PROPEP 16..45
FT /evidence="ECO:0000305|PubMed:29283511"
FT /id="PRO_0000444774"
FT PEPTIDE 46..61
FT /note="Conotoxin reg3.7"
FT /evidence="ECO:0000305|PubMed:29283511"
FT /id="PRO_5014321495"
FT REGION 17..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 61
FT /note="Cysteine amide"
FT /evidence="ECO:0000305"
FT DISULFID 46..60
FT /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT DISULFID 47..58
FT /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT DISULFID 52..61
FT /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT NON_TER 1
FT /evidence="ECO:0000312|EMBL:AUJ88065.1"
SQ SEQUENCE 62 AA; 6918 MW; F5DB60C7E54CDACB CRC64;
RVLLTICLLL FPLSALPLDG DQPADQPARH MQSAERNPRF DPVKRCCPYP SCIDIPFCDC
CG