ID   CM3A_CONAC              Reviewed;          15 AA.
AC   P0DQV5;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Conotoxin ArchIIIA {ECO:0000303|PubMed:35307452};
DE   AltName: Full=F27-1 {ECO:0000303|PubMed:35307452};
OS   Conus archon (Cone snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=257315;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   3D-STRUCTURE MODELING.
RC   TISSUE=Venom;
RX   PubMed=35307452; DOI=10.1016/j.peptides.2022.170785;
RA   Hernandez-Samano A.C., Falcon A., Zamudio F., Michel-Morfin J.E.,
RA   Landa-Jaime V., Lopez-Vera E., Jeziorski M.C., Aguilar M.B.;
RT   "A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous
RT   species, Conus archon, inhibits human neuronal nicotinic acetylcholine
RT   receptors.";
RL   Peptides 153:170785-170785(2022).
CC   -!- FUNCTION: Slowly and reversibly inhibits human nicotinic acetylcholine
CC       receptors (nAChR) alpha-7/CHRNA7 (IC(50)=45.7 uM). It is unknown
CC       whether it inhibits nAChRs by a competitive or a non-competitive
CC       mechanism. {ECO:0000269|PubMed:35307452}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:35307452}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:35307452}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- PTM: Has a free C-terminus. {ECO:0000269|PubMed:35307452}.
CC   -!- MASS SPECTROMETRY: Mass=1654.6; Method=Electrospray; Note=Monoisotopic
CC       mass.; Evidence={ECO:0000269|PubMed:35307452};
CC   -!- MISCELLANEOUS: Has low or no effect on human alpha-3-beta-2/CHRNA3-
CC       CHRNB2 and alpha-7-beta-2/CHRNA7-CHRNB2 nAChR.
CC       {ECO:0000269|PubMed:35307452}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Amidation;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..15
FT                   /note="Conotoxin ArchIIIA"
FT                   /evidence="ECO:0000269|PubMed:35307452"
FT                   /id="PRO_0000456334"
FT   DISULFID        1..15
FT                   /evidence="ECO:0000250|UniProtKB:P85021"
FT   DISULFID        2..11
FT                   /evidence="ECO:0000250|UniProtKB:P85021"
FT   DISULFID        6..14
FT                   /evidence="ECO:0000250|UniProtKB:P85021"
SQ   SEQUENCE   15 AA;  1662 MW;  7233764B6D3C26CB CRC64;
     CCSALCSRYH CLPCC