ID   CM3A_CONBY              Reviewed;          70 AA.
AC   P0DTJ4;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=Conotoxin ba3a {ECO:0000303|PubMed:33916793};
DE   Flags: Precursor;
OS   Conus bayani (Bayan's cone) (Stellaconus bayani).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Splinoconus.
OX   NCBI_TaxID=2070216;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 56-70, MASS SPECTROMETRY,
RP   AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=33916793; DOI=10.3390/md19040202;
RA   Rajaian Pushpabai R., Wilson Alphonse C.R., Mani R., Arun Apte D.,
RA   Franklin J.B.;
RT   "Diversity of Conopeptides and Conoenzymes from the Venom Duct of the
RT   Marine Cone Snail Conus bayani as Determined from Transcriptomic and
RT   Proteomic Analyses.";
RL   Mar. Drugs 19:0-0(2021).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33916793}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:33916793}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       1 branch, since 1 residue stands between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1524.3; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:33916793};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..55
FT                   /evidence="ECO:0000305|PubMed:33916793"
FT                   /id="PRO_0000454984"
FT   PEPTIDE         56..70
FT                   /note="Conotoxin ba3a"
FT                   /evidence="ECO:0000269|PubMed:33916793"
FT                   /id="PRO_0000454985"
SQ   SEQUENCE   70 AA;  7809 MW;  99CB5CDEE7D5BC4E CRC64;
     MLKIGVMLSI ILVLFPLATL QLVAERPAAE RYAENKQDLN PDERRNYLVD LGVERTCCTA
     CNIPPCKCCA