CM3A_CONCN
ID CM3A_CONCN Reviewed; 22 AA.
AC P0C1T9;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Mu-conotoxin CnIIIA {ECO:0000303|PubMed:16533055};
OS Conus consors (Singed cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX NCBI_TaxID=101297;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS, AND AMIDATION AT CYS-22.
RC TISSUE=Venom duct;
RX PubMed=16533055; DOI=10.1021/bi052162j;
RA Zhang M.-M., Fiedler B., Green B.R., Catlin P., Watkins M., Garrett J.E.,
RA Smith B.J., Yoshikami D., Olivera B.M., Bulaj G.;
RT "Structural and functional diversities among mu-conotoxins targeting TTX-
RT resistant sodium channels.";
RL Biochemistry 45:3723-3732(2006).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=19457347; DOI=10.1016/j.jprot.2009.01.019;
RA Biass D., Dutertre S., Gerbault A., Menou J.L., Offord R., Favreau P.,
RA Stocklin R.;
RT "Comparative proteomic study of the venom of the piscivorous cone snail
RT Conus consors.";
RL J. Proteomics 72:210-218(2009).
RN [3]
RP FUNCTION ON SODIUM CHANNELS, SYNTHESIS, AND AMIDATION AT CYS-22.
RX PubMed=21652775; DOI=10.1073/pnas.1107027108;
RA Wilson M.J., Yoshikami D., Azam L., Gajewiak J., Olivera B.M., Bulaj G.,
RA Zhang M.M.;
RT "mu-Conotoxins that differentially block sodium channels Nav1.1 through 1.8
RT identify those responsible for action potentials in sciatic nerve.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:10302-10307(2011).
CC -!- FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This
CC synthetic toxin moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A,
CC rNav1.3/SCN3A, rNav1.4/SCN4A, rNav1.5/SCN5A, and mNav1.6/SCN8A
CC (PubMed:21652775). This block is very slowly reversible
CC (PubMed:16533055). Causes seizures when injected intracranially into
CC mice. {ECO:0000269|PubMed:16533055, ECO:0000269|PubMed:21652775}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:16533055}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct. Has not been isolated
CC from the crude venom. {ECO:0000269|PubMed:19457347}.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC 5 branch, since 5 residues stand between the fourth and the fifth
CC cysteine residues. {ECO:0000305}.
CC -!- MISCELLANEOUS: Does not inhibit Nav1.7/SCN9A and Nav1.8/SCN10A.
CC {ECO:0000305|PubMed:21652775}.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C1T9; -.
DR ConoServer; 1693; CnIIIA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT PEPTIDE 1..22
FT /note="Mu-conotoxin CnIIIA"
FT /evidence="ECO:0000305|PubMed:16533055"
FT /id="PRO_0000249198"
FT MOD_RES 22
FT /note="Cysteine amide"
FT /evidence="ECO:0000305|PubMed:16533055,
FT ECO:0000305|PubMed:21652775"
FT DISULFID 3..15
FT /evidence="ECO:0000250"
FT DISULFID 4..21
FT /evidence="ECO:0000250"
FT DISULFID 10..22
FT /evidence="ECO:0000250"
SQ SEQUENCE 22 AA; 2441 MW; F6F38E05150BD1ED CRC64;
GRCCDVPNAC SGRWCRDHAQ CC