ID   CM3B_CONAO              Reviewed;          16 AA.
AC   C0HKY6;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2017, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Conotoxin ar3b {ECO:0000303|PubMed:26100663};
DE   Contains:
DE     RecName: Full=Conotoxin ar3a {ECO:0000303|PubMed:26100663};
OS   Conus araneosus (Cobweb cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=101286;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=26100663; DOI=10.1016/j.toxicon.2015.06.017;
RA   Franklin J.B., Rajesh R.P.;
RT   "A sleep-inducing peptide from the venom of the Indian cone snail Conus
RT   araneosus.";
RL   Toxicon 103:39-47(2015).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26100663}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:26100663}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       1 branch, since 1 residue stands between the fourth and the fifth
CC       cysteine residues. {ECO:0000303|PubMed:26100663}.
CC   -!- MASS SPECTROMETRY: [Conotoxin ar3b]: Mass=1812.5; Method=MALDI;
CC       Note=Conotoxin ar3b.; Evidence={ECO:0000269|PubMed:26100663};
CC   -!- MASS SPECTROMETRY: [Conotoxin ar3a]: Mass=1755.5; Method=MALDI;
CC       Note=Conotoxin ar3a.; Evidence={ECO:0000269|PubMed:26100663};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKY6; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   PEPTIDE         1..16
FT                   /note="Conotoxin ar3b"
FT                   /evidence="ECO:0000269|PubMed:26100663"
FT                   /id="PRO_0000441661"
FT   PEPTIDE         1..15
FT                   /note="Conotoxin ar3a"
FT                   /evidence="ECO:0000269|PubMed:26100663"
FT                   /id="PRO_0000441662"
FT   DISULFID        1..13
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        2..11
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        7..14
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   UNSURE          10
FT                   /note="I or L"
FT                   /evidence="ECO:0000303|PubMed:26100663"
SQ   SEQUENCE   16 AA;  1820 MW;  35EEB221B631B68C CRC64;
     CCDWDWCDHI CTCCGG