CM3B_CONCN
ID CM3B_CONCN Reviewed; 25 AA.
AC P0C1U0;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Mu-conotoxin CnIIIB;
OS Conus consors (Singed cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX NCBI_TaxID=101297;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS.
RC TISSUE=Venom duct;
RX PubMed=16533055; DOI=10.1021/bi052162j;
RA Zhang M.-M., Fiedler B., Green B.R., Catlin P., Watkins M., Garrett J.E.,
RA Smith B.J., Yoshikami D., Olivera B.M., Bulaj G.;
RT "Structural and functional diversities among mu-conotoxins targeting TTX-
RT resistant sodium channels.";
RL Biochemistry 45:3723-3732(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], PYROGLUTAMATE FORMATION AT GLN-1, MASS
RP SPECTROMETRY, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Venom, and Venom duct;
RX PubMed=22705119; DOI=10.1016/j.jprot.2012.06.001;
RA Violette A., Biass D., Dutertre S., Koua D., Piquemal D., Pierrat F.,
RA Stocklin R., Favreau P.;
RT "Large-scale discovery of conopeptides and conoproteins in the injectable
RT venom of a fish-hunting cone snail using a combined proteomic and
RT transcriptomic approach.";
RL J. Proteomics 75:5215-5225(2012).
CC -!- FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This
CC synthetic toxin blocks slightly but irreversibly tetrodotoxin-resistant
CC VGSCs.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC 5 branch, since 5 residues stand between the fourth and the fifth
CC cysteine residues.
CC -!- MASS SPECTROMETRY: Mass=2939.12; Method=Electrospray; Note=CnIIIB.;
CC Evidence={ECO:0000269|PubMed:22705119};
CC -!- MASS SPECTROMETRY: Mass=2922.17; Method=Electrospray; Note=[Gln1]-
CC CnIIIB.; Evidence={ECO:0000269|PubMed:22705119};
CC -!- MISCELLANEOUS: Found in injectable (milked) (IV) venom.
CC {ECO:0000305|PubMed:22705119}.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C1U0; -.
DR ConoServer; 1690; CnIIIB.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Pyrrolidone carboxylic acid; Secreted; Toxin;
KW Voltage-gated sodium channel impairing toxin.
FT PEPTIDE 1..25
FT /note="Mu-conotoxin CnIIIB"
FT /id="PRO_0000249199"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid; partial"
FT /evidence="ECO:0000269|PubMed:22705119"
FT DISULFID 3..15
FT /evidence="ECO:0000250"
FT DISULFID 4..21
FT /evidence="ECO:0000250"
FT DISULFID 10..22
FT /evidence="ECO:0000250"
SQ SEQUENCE 25 AA; 2947 MW; 81D3BA792B66CA0A CRC64;
QGCCGEPNLC FTRWCRNNAR CCRQQ