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CM3B_CONCN
ID   CM3B_CONCN              Reviewed;          25 AA.
AC   P0C1U0;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Mu-conotoxin CnIIIB;
OS   Conus consors (Singed cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=101297;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS.
RC   TISSUE=Venom duct;
RX   PubMed=16533055; DOI=10.1021/bi052162j;
RA   Zhang M.-M., Fiedler B., Green B.R., Catlin P., Watkins M., Garrett J.E.,
RA   Smith B.J., Yoshikami D., Olivera B.M., Bulaj G.;
RT   "Structural and functional diversities among mu-conotoxins targeting TTX-
RT   resistant sodium channels.";
RL   Biochemistry 45:3723-3732(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], PYROGLUTAMATE FORMATION AT GLN-1, MASS
RP   SPECTROMETRY, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=22705119; DOI=10.1016/j.jprot.2012.06.001;
RA   Violette A., Biass D., Dutertre S., Koua D., Piquemal D., Pierrat F.,
RA   Stocklin R., Favreau P.;
RT   "Large-scale discovery of conopeptides and conoproteins in the injectable
RT   venom of a fish-hunting cone snail using a combined proteomic and
RT   transcriptomic approach.";
RL   J. Proteomics 75:5215-5225(2012).
CC   -!- FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This
CC       synthetic toxin blocks slightly but irreversibly tetrodotoxin-resistant
CC       VGSCs.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       5 branch, since 5 residues stand between the fourth and the fifth
CC       cysteine residues.
CC   -!- MASS SPECTROMETRY: Mass=2939.12; Method=Electrospray; Note=CnIIIB.;
CC       Evidence={ECO:0000269|PubMed:22705119};
CC   -!- MASS SPECTROMETRY: Mass=2922.17; Method=Electrospray; Note=[Gln1]-
CC       CnIIIB.; Evidence={ECO:0000269|PubMed:22705119};
CC   -!- MISCELLANEOUS: Found in injectable (milked) (IV) venom.
CC       {ECO:0000305|PubMed:22705119}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C1U0; -.
DR   ConoServer; 1690; CnIIIB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Pyrrolidone carboxylic acid; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   PEPTIDE         1..25
FT                   /note="Mu-conotoxin CnIIIB"
FT                   /id="PRO_0000249199"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid; partial"
FT                   /evidence="ECO:0000269|PubMed:22705119"
FT   DISULFID        3..15
FT                   /evidence="ECO:0000250"
FT   DISULFID        4..21
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..22
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   25 AA;  2947 MW;  81D3BA792B66CA0A CRC64;
     QGCCGEPNLC FTRWCRNNAR CCRQQ
 
 
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