ID   CM3CF_CONRE             Reviewed;          19 AA.
AC   P85018;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 2.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Conotoxin Reg12f {ECO:0000303|PubMed:17153339};
OS   Conus regius (Crown cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=101314;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND HYDROXYLATION AT PRO-5; PRO-15
RP   AND PRO-18.
RC   TISSUE=Venom;
RX   PubMed=17153339; DOI=10.1007/978-3-540-30880-5_4;
RA   Franco A., Pisarewicz K., Moller C., Mora D., Fields G.B., Mari F.;
RT   "Hyperhydroxylation: a new strategy for neuronal targeting by venomous
RT   marine molluscs.";
RL   Prog. Mol. Subcell. Biol. 43:83-103(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17153339}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:17153339}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       1 branch, since 1 residue stands between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P85018; -.
DR   ConoServer; 1492; Reg12f.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation; Secreted; Toxin.
FT   PEPTIDE         1..19
FT                   /note="Conotoxin Reg12f"
FT                   /evidence="ECO:0000269|PubMed:17153339"
FT                   /id="PRO_0000259392"
FT   MOD_RES         5
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:17153339"
FT   MOD_RES         15
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:17153339"
FT   MOD_RES         18
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:17153339"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        3..14
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        8..17
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
SQ   SEQUENCE   19 AA;  2068 MW;  B23A338D24DB3392 CRC64;
     GCCSPWNCIQ LRACPCCPN