ID   CM3F_CONMR              Reviewed;          71 AA.
AC   P0C425; F6LPM8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Conotoxin mr3f;
DE   AltName: Full=Conotoxin Mr3.9;
DE   Flags: Precursor;
OS   Conus marmoreus (Marble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=42752;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=22781954; DOI=10.1016/j.toxicon.2012.06.011;
RA   Liu Z., Li H., Liu N., Wu C., Jiang J., Yue J., Jing Y., Dai Q.;
RT   "Diversity and evolution of conotoxins in Conus virgo, Conus eburneus,
RT   Conus imperialis and Conus marmoreus from the South China Sea.";
RL   Toxicon 60:982-989(2012).
RN   [2]
RP   PROTEIN SEQUENCE OF 55-70, AMIDATION AT ASP-70, MASS SPECTROMETRY,
RP   BIOASSAY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=17042781; DOI=10.1111/j.1742-4658.2006.05493.x;
RA   Han Y.-H., Wang Q., Jiang H., Liu L., Xiao C., Yuan D.-D., Shao X.-X.,
RA   Dai Q.-Y., Cheng J.-S., Chi C.-W.;
RT   "Characterization of novel M-superfamily conotoxins with new disulfide
RT   linkage.";
RL   FEBS J. 273:4972-4982(2006).
CC   -!- FUNCTION: Intracranially injection into mice does not elicit symptoms.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22781954}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:22781954}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       1 branch, since 1 residue stands between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1694.2; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17042781};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   EMBL; JF322916; ADZ74145.1; -; mRNA.
DR   AlphaFoldDB; P0C425; -.
DR   SMR; P0C425; -.
DR   ConoServer; 1485; MrIIIF.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..53
FT                   /id="PRO_0000425739"
FT   PEPTIDE         55..70
FT                   /note="Conotoxin mr3f"
FT                   /id="PRO_0000289868"
FT   MOD_RES         70
FT                   /note="Aspartic acid 1-amide"
FT                   /evidence="ECO:0000269|PubMed:17042781"
FT   DISULFID        56..68
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        57..66
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        62..69
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
SQ   SEQUENCE   71 AA;  7898 MW;  788F684097B04C2A CRC64;
     MLKMGVVLFI VLVLFPLATL QLDADKPVER YAENKQLLNP DERRGIILHA LGQRVCCPFG
     GCHELCLCCD G