ID   CM401_CONAE             Reviewed;          48 AA.
AC   Q9BP44;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Conotoxin ArMLKMS-01;
DE   Flags: Precursor; Fragment;
OS   Conus arenatus (Sand-dusted cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC   -!- PTM: Contains 3 disulfide bonds (By similarity). They are not added,
CC       since framework IV presents two different connectivities (I-V, II-III,
CC       IV-VI and I-III, II-V, IV-VI). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   EMBL; AF215129; AAG60534.1; -; mRNA.
DR   AlphaFoldDB; Q9BP44; -.
DR   ConoServer; 790; ArMLKMS-01 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Neurotoxin; Pyrrolidone carboxylic acid; Secreted; Toxin.
FT   PROPEP          <1..26
FT                   /id="PRO_0000404926"
FT   PEPTIDE         27..48
FT                   /note="Conotoxin ArMLKMS-01"
FT                   /id="PRO_0000404927"
FT   MOD_RES         27
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   48 AA;  5563 MW;  F830DCF58A7E747F CRC64;
     LFERYAENKQ DLSPDERMGF ILSALRQQEC CVYPFCDGGC YTCQDSCE