ID   CM4A_CONPE              Reviewed;          17 AA.
AC   P58926;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-JUL-2002, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Mu-conotoxin PnIVA;
OS   Conus pennaceus (Feathered cone) (Conus episcopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Darioconus.
OX   NCBI_TaxID=37335;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RX   PubMed=7612605; DOI=10.1021/bi00027a014;
RA   Fainzilber M., Nakamura T., Gaathon A., Lodder J.C., Kits K.S.,
RA   Burlingame A.L., Zlotkin E.;
RT   "A new cysteine framework in sodium channel blocking conotoxins.";
RL   Biochemistry 34:8649-8656(1995).
CC   -!- FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav).
CC       Blocks reversibly sodium channels in molluskan neurons, but has no
CC       effect on sodium currents in bovine chromaffin cells or in rat brain
CC       synaptosomes. Induces paralysis in bivalve mollusks (Mytilus). No
CC       effect are observed on fish (Gambusia) and fly larvae (Sarcophaga).
CC       PnIVB is approximately 6 times more potent than PnIVA in blockade of
CC       the sodium current in Lymnaea neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC   -!- PTM: Contains 3 disulfide bonds (By similarity). They are not added,
CC       since framework IV presents two different connectivities (I-V, II-III,
CC       IV-VI and I-III, II-V, IV-VI). {ECO:0000250}.
CC   -!- MASS SPECTROMETRY: Mass=1789.5; Method=LSI;
CC       Evidence={ECO:0000269|PubMed:7612605};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P58926; -.
DR   ConoServer; 1560; PnIVA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   PEPTIDE         1..17
FT                   /note="Mu-conotoxin PnIVA"
FT                   /id="PRO_0000044496"
FT   SITE            4
FT                   /note="Important for binding and activity"
SQ   SEQUENCE   17 AA;  1797 MW;  F9B721E0E96B9D82 CRC64;
     CCKYGWTCLL GCSPCGC