ID   CMAT_CONPO              Reviewed;          14 AA.
AC   P0C260;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   22-APR-2020, entry version 24.
DE   RecName: Full=Conomap-Vt;
DE            Short=Conp-Vt;
OS   Conus planorbis (Planorbis cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX   NCBI_TaxID=97183;
RN   [1]
RP   PROTEIN SEQUENCE, SYNTHESIS, D-AMINO ACID AT PHE-2, AMIDATION AT TYR-14,
RP   MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=16797543; DOI=10.1016/j.febslet.2006.06.011;
RA   Dutertre S., Lumsden N.G., Alewood P.F., Lewis R.J.;
RT   "Isolation and characterisation of conomap-Vt, a D-amino acid containing
RT   excitatory peptide from the venom of a vermivorous cone snail.";
RL   FEBS Lett. 580:3860-3866(2006).
CC   -!- FUNCTION: Is a potent and mollusk specific excitatory peptide. Most
CC       potent excitatory effect are observed on the buccal mass. It interacts
CC       with non-cholinergic receptors. As this peptide is a major component of
CC       the venom, it may play an important role in prey capture.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16797543}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1488.86; Method=Unknown;
CC       Evidence={ECO:0000269|PubMed:16797543};
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; D-amino acid; Direct protein sequencing; Neurotoxin; Secreted;
KW   Toxin.
FT   PEPTIDE         1..14
FT                   /note="Conomap-Vt"
FT                   /id="PRO_0000262691"
FT   MOD_RES         2
FT                   /note="D-phenylalanine"
FT                   /evidence="ECO:0000269|PubMed:16797543"
FT   MOD_RES         14
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:16797543"
SQ   SEQUENCE   14 AA;  1491 MW;  C8D0B2081A5A13DD CRC64;
     AFVKGSAQRV AHGY