ID   CMB1_SCHPO              Reviewed;         223 AA.
AC   Q10241;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Mismatch-binding protein cmb1;
GN   Name=cmb1; ORFNames=SPAC4G9.11c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=9804804; DOI=10.1074/jbc.273.46.30398;
RA   Fleck O., Kunz C., Rudolph C., Kohli J.;
RT   "The high mobility group domain protein cmb1 of Schizosaccharomyces pombe
RT   binds to cytosines in base mismatches and opposite chemically altered
RT   guanines.";
RL   J. Biol. Chem. 273:30398-30405(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Binds to cytosines in base mismatches and opposite chemically
CC       altered guanines.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; AJ002513; CAA05504.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAA93561.1; -; Genomic_DNA.
DR   PIR; T38870; T38870.
DR   RefSeq; NP_593693.1; NM_001019125.2.
DR   AlphaFoldDB; Q10241; -.
DR   SMR; Q10241; -.
DR   BioGRID; 280010; 8.
DR   STRING; 4896.SPAC4G9.11c.1; -.
DR   MaxQB; Q10241; -.
DR   PaxDb; Q10241; -.
DR   PRIDE; Q10241; -.
DR   EnsemblFungi; SPAC4G9.11c.1; SPAC4G9.11c.1:pep; SPAC4G9.11c.
DR   GeneID; 2543595; -.
DR   KEGG; spo:SPAC4G9.11c; -.
DR   PomBase; SPAC4G9.11c; cmb1.
DR   VEuPathDB; FungiDB:SPAC4G9.11c; -.
DR   eggNOG; KOG0381; Eukaryota.
DR   HOGENOM; CLU_1262183_0_0_1; -.
DR   InParanoid; Q10241; -.
DR   OMA; QIRDVYS; -.
DR   PhylomeDB; Q10241; -.
DR   Reactome; R-SPO-140342; Apoptosis induced DNA fragmentation.
DR   Reactome; R-SPO-163282; Mitochondrial transcription initiation.
DR   PRO; PR:Q10241; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; NAS:PomBase.
DR   GO; GO:0032136; F:adenine/cytosine mispair binding; IDA:PomBase.
DR   GO; GO:0035486; F:cytosine/cytosine mispair binding; IDA:PomBase.
DR   GO; GO:0035488; F:cytosine/thymine mispair binding; IDA:PomBase.
DR   GO; GO:0003684; F:damaged DNA binding; IDA:PomBase.
DR   GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IDA:PomBase.
DR   GO; GO:0032141; F:single cytosine insertion binding; IDA:PomBase.
DR   GO; GO:0035487; F:thymine/thymine mispair binding; IDA:PomBase.
DR   GO; GO:0006281; P:DNA repair; TAS:PomBase.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..223
FT                   /note="Mismatch-binding protein cmb1"
FT                   /id="PRO_0000048805"
FT   DNA_BIND        147..221
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   223 AA;  26304 MW;  8E04A97616A55AEC CRC64;
     MRLFDAMPPY LTYQAPLSLI IFHKMVFAIR IRQFHTTLVS AEKNGLQKLI PPRLKTIWNQ
     MLVETKGAGN GPERFEMIRQ KYKALTADEI QKYKNKLQEQ FDAEKKRFME TLRSFTPTEI
     DSENRRRSKE AHSTGSRYYR LRHPDVPKKP SSAFILFYKE LRNNPKLRQE LGIPEAISTL
     VEETQNASKA WKELAEDKKK PFIDKSKALK EQYDKFMKEA GFR