CMBB_DICDI
ID CMBB_DICDI Reviewed; 413 AA.
AC Q54JC0; Q9U7C8;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Calmodulin-binding protein CmbB;
DE AltName: Full=CaM-BP46;
GN Name=cmbB {ECO:0000312|EMBL:EAL63353.1}; ORFNames=DDB_G0288131;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD56609.1}
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CALMODULIN, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=AX3 {ECO:0000269|PubMed:16777069};
RX PubMed=16777069; DOI=10.1016/j.bbrc.2006.05.204;
RA O'Day D.H., Suhre K., Myre M.A., Chatterjee-Chakraborty M., Chavez S.E.;
RT "Isolation, characterization, and bioinformatic analysis of calmodulin-
RT binding protein cmbB reveals a novel tandem IP22 repeat common to many
RT Dictyostelium and Mimivirus proteins.";
RL Biochem. Biophys. Res. Commun. 346:879-888(2006).
RN [2] {ECO:0000305, ECO:0000312|EMBL:EAL63353.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000312|EMBL:EAL63353.1};
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBUNIT: Interacts with calmodulin in the presence of Ca(2+).
CC {ECO:0000269|PubMed:16777069}.
CC -!- DEVELOPMENTAL STAGE: Expression levels peak at 4 hours of development
CC after which they decrease steadily. Undetectable after 20 hours of
CC development. {ECO:0000269|PubMed:16777069}.
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DR EMBL; AF140043; AAD56609.1; -; mRNA.
DR EMBL; AAFI02000109; EAL63353.1; -; Genomic_DNA.
DR RefSeq; XP_636873.1; XM_631781.1.
DR AlphaFoldDB; Q54JC0; -.
DR SMR; Q54JC0; -.
DR STRING; 44689.DDB0201645; -.
DR PaxDb; Q54JC0; -.
DR EnsemblProtists; EAL63353; EAL63353; DDB_G0288131.
DR GeneID; 8626485; -.
DR KEGG; ddi:DDB_G0288131; -.
DR dictyBase; DDB_G0288131; cmbB.
DR eggNOG; ENOG502RE30; Eukaryota.
DR HOGENOM; CLU_029080_1_0_1; -.
DR InParanoid; Q54JC0; -.
DR OMA; IVEYHWR; -.
DR PhylomeDB; Q54JC0; -.
DR PRO; PR:Q54JC0; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005516; F:calmodulin binding; IDA:dictyBase.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR008615; FNIP.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF05725; FNIP; 6.
PE 1: Evidence at protein level;
KW Calmodulin-binding; Reference proteome; Repeat.
FT CHAIN 1..413
FT /note="Calmodulin-binding protein CmbB"
FT /id="PRO_0000293626"
FT REPEAT 104..148
FT /note="FNIP 1"
FT /evidence="ECO:0000255"
FT REPEAT 149..192
FT /note="FNIP 2"
FT /evidence="ECO:0000255"
FT REPEAT 222..257
FT /note="FNIP 3"
FT /evidence="ECO:0000255"
FT REPEAT 258..301
FT /note="FNIP 4"
FT /evidence="ECO:0000255"
FT REPEAT 304..343
FT /note="FNIP 5"
FT /evidence="ECO:0000255"
FT REPEAT 344..386
FT /note="FNIP 6"
FT /evidence="ECO:0000255"
FT CONFLICT 48
FT /note="H -> N (in Ref. 1; AAD56609)"
FT /evidence="ECO:0000305"
FT CONFLICT 172..173
FT /note="NQ -> K (in Ref. 1; AAD56609)"
FT /evidence="ECO:0000305"
FT CONFLICT 407..411
FT /note="QGACS -> PRCLVP (in Ref. 1; AAD56609)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 413 AA; 46499 MW; 709AA7C364D1A9EC CRC64;
MTSNHLPHHN LTDEDQQEYN KIFKEFIFNI PHNMNPFSPQ LDEKKNSHIV EYHWRSPSNT
IPSTCNTLYV CFNSPIPVNV IPNNVIILCF LCENKTGFTK GPDFNHPIHP GTIPMSVRYI
YFINATYNKP LIAHALPPSA EYLFLSDCYN QAFRAGDLPP NLNILETGDE YNQPFDPLVI
PKSLRSLFLG KGYNQPLEFG GLTSLTCLVY DEGSISELPI ISLPPNLEFL LLSDAFNHPI
EAGMLPPKLK TLTFGDGFNQ PLAVGTLPPS LENINFGKVF DQPFLPNVLP HHLKSISFHQ
FSYFSQTFEN IPSHVQTVEF GYTYNKPITS LPSHLKYIKF SEKYNHPIDG VLPQSLTHCY
LGKSFKRPLV PGIFPPGLKV LILNGYPKKI PPGTVPANCN FQKNPKQGAC SVM
