ID   CMBL_PONAB              Reviewed;         245 AA.
AC   Q5RBU3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Carboxymethylenebutenolidase homolog;
DE            EC=3.1.-.-;
GN   Name=CMBL;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cysteine hydrolase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dienelactone hydrolase family.
CC       {ECO:0000305}.
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DR   EMBL; CR858540; CAH90767.1; -; mRNA.
DR   RefSeq; NP_001125430.1; NM_001131958.1.
DR   AlphaFoldDB; Q5RBU3; -.
DR   SMR; Q5RBU3; -.
DR   STRING; 9601.ENSPPYP00000017140; -.
DR   ESTHER; ponpy-q5rbu3; CMBL.
DR   Ensembl; ENSPPYT00000017835; ENSPPYP00000017140; ENSPPYG00000015343.
DR   GeneID; 100172338; -.
DR   KEGG; pon:100172338; -.
DR   CTD; 134147; -.
DR   eggNOG; KOG3043; Eukaryota.
DR   GeneTree; ENSGT00390000000183; -.
DR   HOGENOM; CLU_054590_8_2_1; -.
DR   InParanoid; Q5RBU3; -.
DR   OMA; HIKAYVV; -.
DR   OrthoDB; 1275897at2759; -.
DR   TreeFam; TF331795; -.
DR   Proteomes; UP000001595; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR042946; CMBL.
DR   InterPro; IPR002925; Dienelactn_hydro.
DR   PANTHER; PTHR46812; PTHR46812; 1.
DR   Pfam; PF01738; DLH; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Hydrolase; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DG6"
FT   CHAIN           2..245
FT                   /note="Carboxymethylenebutenolidase homolog"
FT                   /id="PRO_0000308190"
FT   ACT_SITE        132
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        179
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        212
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DG6"
FT   MOD_RES         36
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DG6"
FT   MOD_RES         223
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DG6"
SQ   SEQUENCE   245 AA;  28078 MW;  E0F3898320AE0134 CRC64;
     MANEAYPCPC DIGHRLEYGG LGREVQVEHI KAYVTKSPVD AGKAVIVIQD IFGWQLPNTR
     YMADMISGNG YTTIVPDFFV GQEPWDPSGD WSIFPEWLKT RNAQKIDREI SAILKYLKQQ
     CHAQKIGIVG FCWGGIAVHH LMMKYSEFRA GVSVYGIVKD SEDIYNLKNP TLFIFAENDV
     VIPLKDVSLL TQKLKEHCKV EYQIKTFSGQ THGFVHRKRE DCSPADKPYI DEARRNLIEW
     LNKYM