ID   CMBL_XENLA              Reviewed;         246 AA.
AC   Q5XH09;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Carboxymethylenebutenolidase homolog;
DE            EC=3.1.-.-;
GN   Name=cmbl;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cysteine hydrolase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dienelactone hydrolase family.
CC       {ECO:0000305}.
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DR   EMBL; BC084267; AAH84267.1; -; mRNA.
DR   RefSeq; NP_001088265.1; NM_001094796.1.
DR   AlphaFoldDB; Q5XH09; -.
DR   SMR; Q5XH09; -.
DR   ESTHER; xenla-q5xh09; CMBL.
DR   MaxQB; Q5XH09; -.
DR   DNASU; 495096; -.
DR   GeneID; 495096; -.
DR   KEGG; xla:495096; -.
DR   CTD; 495096; -.
DR   Xenbase; XB-GENE-5806042; cmbl.L.
DR   OMA; HIKAYVV; -.
DR   OrthoDB; 1275897at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 495096; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR042946; CMBL.
DR   InterPro; IPR002925; Dienelactn_hydro.
DR   PANTHER; PTHR46812; PTHR46812; 1.
DR   Pfam; PF01738; DLH; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..246
FT                   /note="Carboxymethylenebutenolidase homolog"
FT                   /id="PRO_0000308192"
FT   ACT_SITE        132
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        179
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        212
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   246 AA;  28558 MW;  317A4F7708F53973 CRC64;
     MANEACPCPC DIGDKFEYGA KGQEIQIEHI KAYVSKPHSS TDKAVIVVQD IFGWQLPNTR
     FMADLLTAHG YITICPDFFV GQESWKPSND WSTFTEWLQT RQATKVEKEM NVVLKYLKEQ
     CHVKKIGVIG FCWGGVVTHH LMLKYPELKA GVSFYGIIRD VEDRYNLLNP TLFIFAEIDH
     VIPLEQVSLL EQKLKVHSKV DFQIKVFPKQ THGFVHRKKE DINPEDKPFI EEARKDMLEW
     LQKYIN