ID   CMBL_XENTR              Reviewed;         246 AA.
AC   Q6P7K0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Carboxymethylenebutenolidase homolog;
DE            EC=3.1.-.-;
GN   Name=cmbl; ORFNames=TGas069i06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cysteine hydrolase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dienelactone hydrolase family.
CC       {ECO:0000305}.
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DR   EMBL; CR761635; CAJ83783.1; -; mRNA.
DR   EMBL; BC061630; AAH61630.1; -; mRNA.
DR   EMBL; BC082501; AAH82501.1; -; mRNA.
DR   RefSeq; NP_988901.1; NM_203570.1.
DR   AlphaFoldDB; Q6P7K0; -.
DR   SMR; Q6P7K0; -.
DR   ESTHER; xentr-q6p7k0; CMBL.
DR   PaxDb; Q6P7K0; -.
DR   DNASU; 394496; -.
DR   Ensembl; ENSXETT00000054521; ENSXETP00000054521; ENSXETG00000025629.
DR   GeneID; 394496; -.
DR   KEGG; xtr:394496; -.
DR   CTD; 134147; -.
DR   Xenbase; XB-GENE-5806009; cmbl.
DR   eggNOG; KOG3043; Eukaryota.
DR   HOGENOM; CLU_054590_8_2_1; -.
DR   InParanoid; Q6P7K0; -.
DR   OMA; HPSMLEK; -.
DR   OrthoDB; 1275897at2759; -.
DR   PhylomeDB; Q6P7K0; -.
DR   TreeFam; TF331795; -.
DR   Reactome; R-XTR-211945; Phase I - Functionalization of compounds.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000025629; Expressed in liver and 13 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR042946; CMBL.
DR   InterPro; IPR002925; Dienelactn_hydro.
DR   PANTHER; PTHR46812; PTHR46812; 1.
DR   Pfam; PF01738; DLH; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..246
FT                   /note="Carboxymethylenebutenolidase homolog"
FT                   /id="PRO_0000308193"
FT   ACT_SITE        132
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        179
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        212
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   246 AA;  28471 MW;  F50B3E35A758AEE5 CRC64;
     MANEACPCPC DIGDKIEYGA KGQEVQIEHI KAYVSKPHSS TDKAVIVVQD IFGWQLPNTR
     FMADLLTAHG YITICPDFFV GQEPWKPSND RSTFTEWLQT RQATKVEKEI NVVLKYLKEQ
     CHVKKIGVIG FCWGGVVTHH LMLKYPELKA GVSFYGIIRD VEDRYNLLNP TLFIFAEMDH
     VIPLEQVSLL EEKLKVHSKV DFQVKVFPKQ THGFVHRKNE DINPEDKPFI EEARKNMLEW
     LHKYIN