CMC1_YEAST
ID CMC1_YEAST Reviewed; 494 AA.
AC D6W196; P48233; Q45TY5; Q6WV05; Q96US1;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Truncated non-functional calcium-binding mitochondrial carrier SAL1-1;
DE AltName: Full=Suppressor of AAC2 lethality;
GN Name=SAL1; OrderedLocusNames=YNL083W; ORFNames=N2312;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8740422;
RX DOI=10.1002/(sici)1097-0061(199604)12:5<485::aid-yea928>3.0.co;2-u;
RA Soler-Mira A., Saiz J.E., Ballesta J.P.G., Remacha M.A.;
RT "The sequence of a 17,933 bp segment of Saccharomyces cerevisiae chromosome
RT XIV contains the RHO2, TOP2, MKT1 and END3 genes and five new open reading
RT frames.";
RL Yeast 12:485-491(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8701611;
RX DOI=10.1002/(sici)1097-0061(19960330)12:4<391::aid-yea921>3.0.co;2-n;
RA Poehlmann R., Philippsen P.;
RT "Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV
RT reveals 12 new open reading frames (ORFs) and an ancient duplication of six
RT ORFs.";
RL Yeast 12:391-402(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 364-436.
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA Gates K., Gaffney T.D., Philippsen P.;
RT "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT comparison to the genome of a related fungus: Ashbya gossypii.";
RL Genome Biol. 4:R45.1-R45.13(2003).
RN [6]
RP IDENTIFICATION OF PROBABLE FRAMESHIFT.
RX PubMed=9178508;
RX DOI=10.1002/(sici)1097-0061(199705)13:6<573::aid-yea107>3.0.co;2-i;
RA el Moualij B., Duyckaerts C., Lamotte-Brasseur J., Sluse F.E.;
RT "Phylogenetic classification of the mitochondrial carrier family of
RT Saccharomyces cerevisiae.";
RL Yeast 13:573-581(1997).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP FUNCTION, AND IDENTIFICATION OF FRAMESHIFT IN SAL1-1.
RC STRAIN=M2915-6A;
RX PubMed=15238515; DOI=10.1534/genetics.103.023655;
RA Chen X.J.;
RT "Sal1p, a calcium-dependent carrier protein that suppresses an essential
RT cellular function associated With the Aac2 isoform of ADP/ATP translocase
RT in Saccharomyces cerevisiae.";
RL Genetics 167:607-617(2004).
RN [9]
RP CONFIRMATION OF FRAMESHIFT IN SAL1-1.
RC STRAIN=ATCC 200879 / BY4716, and ATCC 204508 / S288c;
RX PubMed=19581448; DOI=10.1534/genetics.109.104497;
RA Dimitrov L.N., Brem R.B., Kruglyak L., Gottschling D.E.;
RT "Polymorphisms in multiple genes contribute to the spontaneous
RT mitochondrial genome instability of Saccharomyces cerevisiae S288C
RT strains.";
RL Genetics 183:365-383(2009).
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier.
CC {ECO:0000269|PubMed:15238515}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- CAUTION: Strain S288c has a frameshift in position 403, which disrupts
CC the gene coding for this protein and produces the non-functional allele
CC sal1-1. A full-length functional allele can be found in strain CG379
CC (AC P0CI40). {ECO:0000305}.
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DR EMBL; X89016; CAA61427.1; -; Genomic_DNA.
DR EMBL; Z71359; CAA95958.1; -; Genomic_DNA.
DR EMBL; AY268134; AAR26280.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10462.2; -; Genomic_DNA.
DR PIR; S57539; S57539.
DR RefSeq; NP_014316.3; NM_001182921.1.
DR AlphaFoldDB; D6W196; -.
DR SMR; D6W196; -.
DR BioGRID; 35740; 61.
DR STRING; 4932.YNL083W; -.
DR iPTMnet; D6W196; -.
DR PaxDb; D6W196; -.
DR PRIDE; D6W196; -.
DR GeneID; 855641; -.
DR KEGG; sce:YNL083W; -.
DR SGD; S000005027; SAL1.
DR eggNOG; KOG0036; Eukaryota.
DR HOGENOM; CLU_015166_2_1_1; -.
DR InParanoid; D6W196; -.
DR BioCyc; YEAST:G3O-33112-MON; -.
DR PRO; PR:D6W196; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; D6W196; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005471; F:ATP:ADP antiporter activity; IMP:SGD.
DR GO; GO:0005509; F:calcium ion binding; IDA:SGD.
DR GO; GO:0015866; P:ADP transport; IMP:SGD.
DR GO; GO:0015867; P:ATP transport; IMP:SGD.
DR GO; GO:0006839; P:mitochondrial transport; IMP:SGD.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00153; Mito_carr; 2.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
DR PROSITE; PS50920; SOLCAR; 2.
PE 1: Evidence at protein level;
KW Calcium; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..494
FT /note="Truncated non-functional calcium-binding
FT mitochondrial carrier SAL1-1"
FT /id="PRO_0000402277"
FT TRANSMEM 231..248
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..326
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..368
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..428
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..475
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT DOMAIN 11..46
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 80..115
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 120..155
FT /note="EF-hand 3"
FT /evidence="ECO:0000305"
FT DOMAIN 156..191
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REPEAT 225..332
FT /note="Solcar 1"
FT REPEAT 345..434
FT /note="Solcar 2"
FT REPEAT 452..494
FT /note="Solcar 3; truncated"
FT BINDING 65
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 70
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 95
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 97
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 99
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 104
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 161
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000305"
FT BINDING 166
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="V -> M (in Ref. 3; DAA10462)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 494 AA; 55715 MW; 0AB408E1CED63946 CRC64;
MLLKNCETDK QRDIRYACLF KELDVKGNGQ VTLDNLISAF EKNDHPLKGN DEAIKMLFTA
MDVNKDSVVD LSDFKKYASN AESQIWNGFQ RIDLDHDGKI GINEINRYLS DLDNQSICNN
ELNHELSNEK VNKFSRFFEW AFPKRKANIA LRGQASHKKN TDNDRSKKTT DSDLYVTYDQ
WRDFLLLVPR KQGSRLHTAY SYFYLFNEDV DLSSEGDVTL INDFIRGFGF FIAGGISGVI
SRTCTAPFDR LKVFLIARTD LSSILLNSKT DLLAKNPNAD INKISSPLAK AVKSLYRQGG
IKAFYVGNGL NVIKVFPESS IKFGSFEVTK KIMTKLEGCR DTKDLSKFST YIAGGLAGMA
AQFSVYPIDT LKFRVQCAPL DTKLKGNNLL FQTAKDMFRE GGGQIILQRC HSRYSGHISL
CCIRFGDFFC LKKMVYCQTG KDPEPTTRSG HSKQPGCTSN GCIQWNCRSF CCLSNQSFKN
KTTSPRNICT SLCV