CMC1_YEASX
ID CMC1_YEASX Reviewed; 545 AA.
AC P0CI40; P48233; Q45TY5; Q6WV05; Q96US1;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Calcium-binding mitochondrial carrier SAL1;
DE AltName: Full=Suppressor of AAC2 lethality;
GN Name=SAL1;
OS Saccharomyces cerevisiae (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=4932;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204665 / CG379;
RX PubMed=10930523; DOI=10.1016/s0005-2736(00)00222-4;
RA Belenkiy R., Haefele A., Eisen M.B., Wohlrab H.;
RT "The yeast mitochondrial transport proteins: new sequences and consensus
RT residues, lack of direct relation between consensus residues and
RT transmembrane helices, expression patterns of the transport protein genes,
RT and protein-protein interactions with other proteins.";
RL Biochim. Biophys. Acta 1467:207-218(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-240.
RC STRAIN=SK1;
RX PubMed=16273108; DOI=10.1038/ng1674;
RA Deutschbauer A.M., Davis R.W.;
RT "Quantitative trait loci mapped to single-nucleotide resolution in yeast.";
RL Nat. Genet. 37:1333-1340(2005).
RN [3]
RP FUNCTION, AND IDENTIFICATION OF FRAMESHIFT IN SAL1-1.
RC STRAIN=ATCC 201238 / W303-1B;
RX PubMed=15238515; DOI=10.1534/genetics.103.023655;
RA Chen X.J.;
RT "Sal1p, a calcium-dependent carrier protein that suppresses an essential
RT cellular function associated With the Aac2 isoform of ADP/ATP translocase
RT in Saccharomyces cerevisiae.";
RL Genetics 167:607-617(2004).
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier.
CC {ECO:0000269|PubMed:15238515}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AF419344; AAL26493.1; -; Genomic_DNA.
DR EMBL; DQ115393; AAZ22525.1; -; Genomic_DNA.
DR AlphaFoldDB; P0CI40; -.
DR SMR; P0CI40; -.
DR VEuPathDB; FungiDB:YNL083W; -.
DR OMA; LGIFPYA; -.
DR PhylomeDB; P0CI40; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Repeat; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..545
FT /note="Calcium-binding mitochondrial carrier SAL1"
FT /id="PRO_0000090607"
FT TRANSMEM 231..248
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..326
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..368
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..428
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..475
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..535
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT DOMAIN 11..46
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 80..115
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 120..155
FT /note="EF-hand 3"
FT /evidence="ECO:0000305"
FT DOMAIN 156..191
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REPEAT 225..332
FT /note="Solcar 1"
FT REPEAT 345..434
FT /note="Solcar 2"
FT REPEAT 452..541
FT /note="Solcar 3"
FT BINDING 65
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 70
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 95
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 97
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 99
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 104
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 161
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000305"
FT BINDING 166
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000305"
FT VARIANT 240
FT /note="I -> V (in strain: SK1)"
FT /evidence="ECO:0000269|PubMed:16273108"
SQ SEQUENCE 545 AA; 61270 MW; 8F33AA9AE392538E CRC64;
MLLKNCETDK QRDIRYACLF KELDVKGNGQ VTLDNLISAF EKNDHPLKGN DEAIKMLFTA
MDVNKDSVVD LSDFKKYASN AESQIWNGFQ RIDLDHDGKI GINEINRYLS DLDNQSICNN
ELNHELSNEK MNKFSRFFEW AFPKRKANIA LRGQASHKKN TDNDRSKKTT DSDLYVTYDQ
WRDFLLLVPR KQGSRLHTAY SYFYLFNEDV DLSSEGDVTL INDFIRGFGF FIAGGISGVI
SRTCTAPFDR LKVFLIARTD LSSILLNSKT DLLAKNPNAD INKISSPLAK AVKSLYRQGG
IKAFYVGNGL NVIKVFPESS IKFGSFEVTK KIMTKLEGCR DTKDLSKFST YIAGGLAGMA
AQFSVYPIDT LKFRVQCAPL DTKLKGNNLL FQTAKDMFRE GGLRLFYRGV TVGIVGIFPY
AALDLGTFSA LKKWYIAKQA KTLNLPQDQV TLSNLVVLPM GAFSGTVGAS VVYPINLLRT
RLQAQGTYAH PYVYNGFKDV LLKTLEREGY QGLFKGLVPT LAKVCPAVSI SYLCYENLKK
FMNLE