ID   2AAA_PEA                Reviewed;         395 AA.
AC   P36875;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Protein phosphatase PP2A regulatory subunit A;
DE   AltName: Full=PR65;
DE   Flags: Fragment;
OS   Pisum sativum (Garden pea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Fabeae; Pisum.
OX   NCBI_TaxID=3888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. JI 813;
RX   PubMed=8155887; DOI=10.1007/bf00023566;
RA   Evans I.M., Fawcett T., Boulter D., Fordham-Skelton A.P.;
RT   "A homologue of the 65 kDa regulatory subunit of protein phosphatase 2A in
RT   early pea (Pisum sativum L.) embryos.";
RL   Plant Mol. Biol. 24:689-695(1994).
CC   -!- FUNCTION: The PR65 subunit of protein phosphatase 2A serves as a
CC       scaffolding molecule to coordinate the assembly of the catalytic
CC       subunit and a variable regulatory B subunit. {ECO:0000250}.
CC   -!- SUBUNIT: PP2A exists in several trimeric forms, all of which consist of
CC       a core composed of a catalytic subunit associated with a 65 kDa
CC       regulatory subunit (PR65) (subunit A). The core complex associates with
CC       a third, variable subunit (subunit B), which confers distinct
CC       properties to the holoenzyme.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit A family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z25888; CAA81107.1; -; mRNA.
DR   PIR; S43776; S40171.
DR   AlphaFoldDB; P36875; -.
DR   SMR; P36875; -.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   Pfam; PF02985; HEAT; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 8.
PE   2: Evidence at transcript level;
KW   Repeat.
FT   CHAIN           <1..395
FT                   /note="Protein phosphatase PP2A regulatory subunit A"
FT                   /id="PRO_0000071412"
FT   REPEAT          44..81
FT                   /note="HEAT 1"
FT   REPEAT          83..120
FT                   /note="HEAT 2"
FT   REPEAT          122..159
FT                   /note="HEAT 3"
FT   REPEAT          161..198
FT                   /note="HEAT 4"
FT   REPEAT          200..237
FT                   /note="HEAT 5"
FT   REPEAT          239..276
FT                   /note="HEAT 6"
FT   REPEAT          279..316
FT                   /note="HEAT 7"
FT   REPEAT          318..355
FT                   /note="HEAT 8"
FT   NON_TER         1
SQ   SEQUENCE   395 AA;  43912 MW;  F444DBDC935F8A04 CRC64;
     VEAAHLKTDI MSVFDDLTQD DQDSFRFLAV EGCAALGKLL EPQDCLAHIL PVIVNFSQDK
     SWRVRYMVAN QLYELCEAVG PDSTKTELVP AYVRLLRDNV AEVRIAAAGK VSKFSRILSP
     ELAIQHILPC VKELSTDSSQ HVRSALASVI MGMAPVLGKD ATIEQLLPIF LSLLKDEFPD
     VRLNIISKLD QVNQVIGIDL LSQSLLPAIV ELAEDRHWRV RLAIIEYIPL LASQLGVGFF
     DDKLGALIMQ WLKDKEYSIR NAAANNVKRL AAEEFGPEWA MQHIIPQVLD MINDPHYLYR
     MTILHAISLL APVLGSEITS TNLLPLVVNA SKDRVPNIKF NVAKVLQSLI PIVDESVVES
     TIRPCLVELS EDPDVDVRFF ASQALQSSDQ VKMSS