CMC3_CAEEL
ID CMC3_CAEEL Reviewed; 531 AA.
AC Q19529;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 4.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Probable calcium-binding mitochondrial carrier F17E5.2;
GN ORFNames=F17E5.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; Z50873; CAA90761.4; -; Genomic_DNA.
DR PIR; G89667; G89667.
DR PIR; T21074; T21074.
DR RefSeq; NP_510081.3; NM_077680.5.
DR AlphaFoldDB; Q19529; -.
DR SMR; Q19529; -.
DR BioGRID; 46304; 2.
DR STRING; 6239.F17E5.2; -.
DR EPD; Q19529; -.
DR PaxDb; Q19529; -.
DR PeptideAtlas; Q19529; -.
DR EnsemblMetazoa; F17E5.2.1; F17E5.2.1; WBGene00008924.
DR EnsemblMetazoa; F17E5.2.2; F17E5.2.2; WBGene00008924.
DR GeneID; 181399; -.
DR KEGG; cel:CELE_F17E5.2; -.
DR UCSC; F17E5.2; c. elegans.
DR CTD; 181399; -.
DR WormBase; F17E5.2; CE37355; WBGene00008924; -.
DR eggNOG; KOG0036; Eukaryota.
DR GeneTree; ENSGT00940000170889; -.
DR HOGENOM; CLU_015166_2_0_1; -.
DR InParanoid; Q19529; -.
DR OMA; DIWMQEG; -.
DR OrthoDB; 442523at2759; -.
DR PhylomeDB; Q19529; -.
DR PRO; PR:Q19529; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00008924; Expressed in embryo and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 3.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..531
FT /note="Probable calcium-binding mitochondrial carrier
FT F17E5.2"
FT /id="PRO_0000090605"
FT TRANSMEM 248..265
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..322
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..361
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..418
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..458
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..517
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT DOMAIN 70..105
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 106..135
FT /note="EF-hand 2"
FT /evidence="ECO:0000305"
FT DOMAIN 136..171
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 172..207
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REPEAT 242..328
FT /note="Solcar 1"
FT REPEAT 338..424
FT /note="Solcar 2"
FT REPEAT 435..525
FT /note="Solcar 3"
FT BINDING 83
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 85
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 87
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 89
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 94
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 149
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 151
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 153
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 155
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 160
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 531 AA; 59275 MW; FE1CC396D6BCB345 CRC64;
MSVTAESPSL RGGSILENKQ ELIDLKNIGE HARTVQPFKT SKHQPLIQGS VSKEAAIATH
SALHFDLTPE KEKKIRDMYD RLDADNDGSI DIRDLTQALS LQAHIPASVA PKLLERMKSE
HSDRVTYADF TNYVIAHEAR LAEVFDKIDL NSDGEVDMAE IKSYCKEMGV NLDDQKAMSI
VKKMDQSGSS SVNLNEFQDF MLLYPSTDMR DMVDFWRHNL IIDIGEDGQV PEDFTPQELL
SGVWWRHLVA GGVAGAMSRT CTAPFDRIKV YLQVNSTKTN KLGVVSCVHL LHAEGGIKSF
WRGNGINVIK IAPESAMKFM CYDQIKRWMQ EYKGGAELST IERLLAGSSA GAISQTAIYP
MEVMKTRLAL RRTGQLDKGM FHFAHKMYTK EGIKCFYKGY LPNLLGIIPY AGIDLTVYES
LKSMYTKYYT EHTEPGVLAL LACGTCSSTC GQLASYPLAL VRTRLQARAI SPKNSTQPDT
MVGQFKHILQ TEGFTGLYRG ITPNFMKVIP AVSISYVVYE KVRKQLGATM T
