ID   CMC4_CANAW              Reviewed;          84 AA.
AC   C4YIM0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Cx9C motif-containing protein 4, mitochondrial;
GN   Name=CMC4; ORFNames=CAWG_04296;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC       Note=Imported into the mitochondria via the mitochondrial disulfide
CC       relay system. {ECO:0000250}.
CC   -!- DOMAIN: The twin Cx9C motifs are involved in the recognition by the
CC       mitochondrial disulfide relay system. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CMC4 family. {ECO:0000305}.
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DR   EMBL; CH672350; EEQ45955.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4YIM0; -.
DR   SMR; C4YIM0; -.
DR   STRING; 5476.C4YIM0; -.
DR   EnsemblFungi; EEQ45955; EEQ45955; CAWG_04296.
DR   VEuPathDB; FungiDB:CAWG_04296; -.
DR   HOGENOM; CLU_177210_0_1_1; -.
DR   OMA; CAIQNCI; -.
DR   Proteomes; UP000001429; Chromosome 2, Supercontig 1.5.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR   InterPro; IPR027179; MTCP1.
DR   PANTHER; PTHR15590; PTHR15590; 1.
DR   Pfam; PF08991; MTCP1; 1.
DR   SUPFAM; SSF47072; SSF47072; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Mitochondrion; Repeat.
FT   CHAIN           1..84
FT                   /note="Cx9C motif-containing protein 4, mitochondrial"
FT                   /id="PRO_0000408571"
FT   DOMAIN          5..47
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           8..18
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           29..39
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        8..39
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        18..29
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   84 AA;  9599 MW;  5613BDF1242EBB15 CRC64;
     MSEVNETCKP QACAIQNCLE KNGYNESRCT KCIDDLYKCC KEFYERQGPD ASSVCCPKFK
     LLQLKLKQRS LGEIDAKVLE TRRG