ID   CMC4_CANTT              Reviewed;          85 AA.
AC   C5M6H7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Cx9C motif-containing protein 4, mitochondrial;
GN   Name=CMC4; ORFNames=CTRG_01458;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC       Note=Imported into the mitochondria via the mitochondrial disulfide
CC       relay system. {ECO:0000250}.
CC   -!- DOMAIN: The twin Cx9C motifs are involved in the recognition by the
CC       mitochondrial disulfide relay system. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CMC4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EER34597.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; GG692396; EER34597.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_002547152.1; XM_002547106.1.
DR   AlphaFoldDB; C5M6H7; -.
DR   SMR; C5M6H7; -.
DR   STRING; 294747.C5M6H7; -.
DR   EnsemblFungi; EER34597; EER34597; CTRG_01458.
DR   GeneID; 8301346; -.
DR   KEGG; ctp:CTRG_01458; -.
DR   eggNOG; ENOG502S7M4; Eukaryota.
DR   HOGENOM; CLU_177210_0_1_1; -.
DR   OrthoDB; 1633942at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR   InterPro; IPR027179; MTCP1.
DR   PANTHER; PTHR15590; PTHR15590; 1.
DR   Pfam; PF08991; MTCP1; 1.
DR   SUPFAM; SSF47072; SSF47072; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Mitochondrion; Reference proteome; Repeat.
FT   CHAIN           1..85
FT                   /note="Cx9C motif-containing protein 4, mitochondrial"
FT                   /id="PRO_0000408572"
FT   DOMAIN          6..48
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           9..19
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           30..40
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        9..40
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        19..30
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   85 AA;  9641 MW;  5B0E74EE6E76D389 CRC64;
     MSDEINETCK PQACAIQNCL MKNGYNESKC SYYIDELYKC CKKFYESNGS SASSVCCPKF
     NLLQLKLKQR ELGQIDANLI DTKHG