ID   CMC4_CLAL4              Reviewed;          87 AA.
AC   C4Y2J3;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Cx9C motif-containing protein 4, mitochondrial;
GN   Name=CMC4; ORFNames=CLUG_02756;
OS   Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Clavispora.
OX   NCBI_TaxID=306902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42720;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC       Note=Imported into the mitochondria via the mitochondrial disulfide
CC       relay system. {ECO:0000250}.
CC   -!- DOMAIN: The twin Cx9C motifs are involved in the recognition by the
CC       mitochondrial disulfide relay system. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CMC4 family. {ECO:0000305}.
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DR   EMBL; CH408078; EEQ38630.1; -; Genomic_DNA.
DR   RefSeq; XP_002617312.1; XM_002617266.1.
DR   AlphaFoldDB; C4Y2J3; -.
DR   SMR; C4Y2J3; -.
DR   STRING; 306902.C4Y2J3; -.
DR   EnsemblFungi; EEQ38630; EEQ38630; CLUG_02756.
DR   GeneID; 8498037; -.
DR   KEGG; clu:CLUG_02756; -.
DR   VEuPathDB; FungiDB:CLUG_02756; -.
DR   HOGENOM; CLU_177210_0_1_1; -.
DR   InParanoid; C4Y2J3; -.
DR   OMA; CAIQNCI; -.
DR   Proteomes; UP000007703; Unassembled WGS sequence.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR   InterPro; IPR027179; MTCP1.
DR   PANTHER; PTHR15590; PTHR15590; 1.
DR   Pfam; PF08991; MTCP1; 1.
DR   SUPFAM; SSF47072; SSF47072; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Mitochondrion; Reference proteome; Repeat.
FT   CHAIN           1..87
FT                   /note="Cx9C motif-containing protein 4, mitochondrial"
FT                   /id="PRO_0000408573"
FT   DOMAIN          9..51
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           12..22
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           33..43
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        12..43
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        22..33
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   87 AA;  9786 MW;  C4BD8CF5A8D40D13 CRC64;
     MSKPESCDEN ACKPFACAIQ DCLIENGYNE SKCTKAIDNL YKCCKQFYEE NGPDAASVCC
     PKFNLLQLKL KQRSLGKIDA ELIQSRK