CMC4_LODEL
ID CMC4_LODEL Reviewed; 90 AA.
AC A5DUN2;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Cx9C motif-containing protein 4, mitochondrial;
GN Name=CMC4; ORFNames=LELG_01068;
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC YB-4239;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC Note=Imported into the mitochondria via the mitochondrial disulfide
CC relay system. {ECO:0000250}.
CC -!- DOMAIN: The twin Cx9C motifs are involved in the recognition by the
CC mitochondrial disulfide relay system. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CMC4 family. {ECO:0000305}.
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DR EMBL; CH981524; EDK42890.1; -; Genomic_DNA.
DR RefSeq; XP_001528548.1; XM_001528498.1.
DR AlphaFoldDB; A5DUN2; -.
DR SMR; A5DUN2; -.
DR STRING; 379508.A5DUN2; -.
DR EnsemblFungi; EDK42890; EDK42890; LELG_01068.
DR GeneID; 5235656; -.
DR KEGG; lel:LELG_01068; -.
DR VEuPathDB; FungiDB:LELG_01068; -.
DR eggNOG; ENOG502S7M4; Eukaryota.
DR HOGENOM; CLU_177210_0_1_1; -.
DR InParanoid; A5DUN2; -.
DR OMA; CAIQNCI; -.
DR OrthoDB; 1633942at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR InterPro; IPR027179; MTCP1.
DR PANTHER; PTHR15590; PTHR15590; 1.
DR Pfam; PF08991; MTCP1; 1.
DR SUPFAM; SSF47072; SSF47072; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Mitochondrion; Reference proteome; Repeat.
FT CHAIN 1..90
FT /note="Cx9C motif-containing protein 4, mitochondrial"
FT /id="PRO_0000408576"
FT DOMAIN 11..53
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 14..24
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 35..45
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 14..45
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 24..35
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 90 AA; 10100 MW; 189C71E37A84782F CRC64;
MSEESQASQA SQACQAKACA IQDCLQGNGY NEAKCTKYID DLYQCCKNFY EENGVDAKSV
CCPKFKLLQL KLKQRSLGQI DATLLENKRH
