CMC4_MOUSE
ID CMC4_MOUSE Reviewed; 68 AA.
AC Q61908;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Cx9C motif-containing protein 4;
DE AltName: Full=Mature T-cell proliferation 1 neighbor protein;
DE AltName: Full=Mature T-cell proliferation-1 type A;
DE Short=MTCP-1 type A;
DE AltName: Full=Protein p8 MTCP-1;
DE Short=p8MTCP1;
GN Name=Cmc4; Synonyms=C6.1b, Mtcp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=7970717;
RA Soulier J., Madani A., Cacheux V., Rosenzwajg M., Sigaux F., Stern M.-H.;
RT "The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed
RT in T cell leukemia bearing a t(X;14) translocation.";
RL Oncogene 9:3565-3570(1994).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=7784073;
RA Madani A., Soulier J., Schmid M., Plichtova R., Lerme F., Gateau-Roesch O.,
RA Garnier J.-P., Pla M., Sigaux F., Stern M.-H.;
RT "The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial
RT protein.";
RL Oncogene 10:2259-2262(1995).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:7784073}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Short, Type A, p8 MTCP-1;
CC IsoId=Q61908-1; Sequence=Displayed;
CC Name=2; Synonyms=Long, Type B1, p13 MTCP-1;
CC IsoId=Q60945-1; Sequence=External;
CC -!- TISSUE SPECIFICITY: Expressed in many tissues.
CC -!- DOMAIN: The twin Cx9C motifs are involved in the recognition by the
CC mitochondrial disulfide relay system. {ECO:0000250}.
CC -!- MISCELLANEOUS: [Isoform 1]: Shares a non-coding 5' exon with isoform 2
CC which is spliced to a different set of 3' exons encoding an unrelated
CC protein.
CC -!- SIMILARITY: Belongs to the CMC4 family. {ECO:0000305}.
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DR EMBL; Z35294; CAA84544.1; -; mRNA.
DR CCDS; CCDS41030.1; -. [Q61908-1]
DR PIR; I48672; I48672.
DR RefSeq; NP_001281206.1; NM_001294277.1. [Q61908-1]
DR RefSeq; NP_034969.1; NM_010839.6. [Q61908-1]
DR AlphaFoldDB; Q61908; -.
DR SMR; Q61908; -.
DR STRING; 10090.ENSMUSP00000033543; -.
DR PhosphoSitePlus; Q61908; -.
DR MaxQB; Q61908; -.
DR PaxDb; Q61908; -.
DR PRIDE; Q61908; -.
DR ProteomicsDB; 283315; -. [Q61908-1]
DR Antibodypedia; 45442; 73 antibodies from 17 providers.
DR Ensembl; ENSMUST00000033543; ENSMUSP00000033543; ENSMUSG00000090110. [Q61908-1]
DR Ensembl; ENSMUST00000120286; ENSMUSP00000112753; ENSMUSG00000090110. [Q61908-1]
DR Ensembl; ENSMUST00000149863; ENSMUSP00000117381; ENSMUSG00000090110. [Q61908-1]
DR GeneID; 105886298; -.
DR KEGG; mmu:105886298; -.
DR UCSC; uc009tpv.2; mouse. [Q61908-1]
DR CTD; 100272147; -.
DR MGI; MGI:5637812; Cmc4.
DR VEuPathDB; HostDB:ENSMUSG00000090110; -.
DR eggNOG; ENOG502SC73; Eukaryota.
DR GeneTree; ENSGT00390000012647; -.
DR HOGENOM; CLU_177210_1_1_1; -.
DR OMA; ICCSGFE; -.
DR PhylomeDB; Q61908; -.
DR TreeFam; TF353119; -.
DR BioGRID-ORCS; 105886298; 0 hits in 33 CRISPR screens.
DR ChiTaRS; Cmc4; mouse.
DR PRO; PR:Q61908; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q61908; protein.
DR Bgee; ENSMUSG00000090110; Expressed in primary oocyte and 251 other tissues.
DR ExpressionAtlas; Q61908; baseline and differential.
DR Genevisible; Q61908; MM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR InterPro; IPR027179; MTCP1.
DR PANTHER; PTHR15590; PTHR15590; 1.
DR Pfam; PF08991; MTCP1; 1.
DR SUPFAM; SSF47072; SSF47072; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Mitochondrion; Reference proteome.
FT CHAIN 1..68
FT /note="Cx9C motif-containing protein 4"
FT /id="PRO_0000096615"
FT DOMAIN 4..46
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 7..17
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 28..38
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 7..38
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 17..28
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 39..50
FT /evidence="ECO:0000250"
SQ SEQUENCE 68 AA; 7743 MW; 396E47FF1403A736 CRC64;
MPQKDPCQKQ ACEIQKCLQA NNYLESKCQA VIQELRKCCA RYPKGRSLVC SGFEKEEEEK
LAMKSGSK
