ID   CMC4_SCHPO              Reviewed;          70 AA.
AC   G2TRJ8;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Cx9C motif-containing protein 4, mitochondrial;
DE   AltName: Full=Transcripts altered in meiosis protein 2;
GN   Name=cmc4; Synonyms=tam2; ORFNames=SPAC4F10.22;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND INDUCTION.
RX   PubMed=21270388; DOI=10.1534/genetics.110.123497;
RA   Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L.,
RA   Hagan I.M., Miller C.J.;
RT   "Augmented annotation of the Schizosaccharomyces pombe genome reveals
RT   additional genes required for growth and viability.";
RL   Genetics 187:1207-1217(2011).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC       Note=Imported into the mitochondria via the mitochondrial mia40-erv1
CC       machinery. {ECO:0000250}.
CC   -!- INDUCTION: Differentially expressed during meiosis.
CC       {ECO:0000269|PubMed:21270388}.
CC   -!- DOMAIN: The twin Cx9C motifs are involved in the recognition by the
CC       mitochondrial mia40-erv1 disulfide relay system and the subsequent
CC       transfer of disulfide bonds by dithiol/disulfide exchange reactions to
CC       the newly imported protein. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CMC4 family. {ECO:0000305}.
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DR   EMBL; CU329670; CCD31341.1; -; Genomic_DNA.
DR   RefSeq; XP_004001796.1; XM_004001747.1.
DR   AlphaFoldDB; G2TRJ8; -.
DR   SMR; G2TRJ8; -.
DR   STRING; 4896.SPAC4F10.22.1; -.
DR   MaxQB; G2TRJ8; -.
DR   PaxDb; G2TRJ8; -.
DR   EnsemblFungi; SPAC4F10.22.1; SPAC4F10.22.1:pep; SPAC4F10.22.
DR   PomBase; SPAC4F10.22; cmc4.
DR   VEuPathDB; FungiDB:SPAC4F10.22; -.
DR   HOGENOM; CLU_177210_0_0_1; -.
DR   InParanoid; G2TRJ8; -.
DR   PRO; PR:G2TRJ8; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISO:PomBase.
DR   InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR   InterPro; IPR027179; MTCP1.
DR   PANTHER; PTHR15590; PTHR15590; 1.
DR   Pfam; PF08991; MTCP1; 1.
DR   SUPFAM; SSF47072; SSF47072; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Mitochondrion; Reference proteome; Repeat.
FT   CHAIN           1..70
FT                   /note="Cx9C motif-containing protein 4, mitochondrial"
FT                   /id="PRO_0000416511"
FT   DOMAIN          1..43
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           4..14
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           25..35
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        4..35
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        14..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   70 AA;  8119 MW;  082397600FC65876 CRC64;
     MVDCQKEACN LQSCIQRNQY NQGNCEKFVN DLLLCCKRWY DKNSLTGNEA PHTCPELKPL
     LRQLSSRNLT