CMC4_YEAST
ID CMC4_YEAST Reviewed; 73 AA.
AC Q3E7A9; D6W019;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Cx9C motif-containing protein 4, mitochondrial;
GN Name=CMC4; OrderedLocusNames=YMR194C-B;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA Gates K., Gaffney T.D., Philippsen P.;
RT "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT comparison to the genome of a related fungus: Ashbya gossypii.";
RL Genome Biol. 4:R45.1-R45.13(2003).
RN [4]
RP DOMAIN, AND SUBCELLULAR LOCATION.
RX PubMed=19703468; DOI=10.1016/j.jmb.2009.08.041;
RA Longen S., Bien M., Bihlmaier K., Kloeppel C., Kauff F., Hammermeister M.,
RA Westermann B., Herrmann J.M., Riemer J.;
RT "Systematic analysis of the twin cx(9)c protein family.";
RL J. Mol. Biol. 393:356-368(2009).
RN [5]
RP DOMAIN.
RX PubMed=20922212; DOI=10.1039/c0mb00058b;
RA Cavallaro G.;
RT "Genome-wide analysis of eukaryotic twin CX9C proteins.";
RL Mol. Biosyst. 6:2459-2470(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=22984289; DOI=10.1074/mcp.m112.021105;
RA Voegtle F.N., Burkhart J.M., Rao S., Gerbeth C., Hinrichs J.,
RA Martinou J.C., Chacinska A., Sickmann A., Zahedi R.P., Meisinger C.;
RT "Intermembrane space proteome of yeast mitochondria.";
RL Mol. Cell. Proteomics 11:1840-1852(2012).
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space
CC {ECO:0000269|PubMed:19703468, ECO:0000269|PubMed:22984289}.
CC Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1
CC machinery.
CC -!- DOMAIN: The twin Cx9C motifs are involved in the recognition by the
CC mitochondrial MIA40-ERV1 disulfide relay system and the subsequent
CC transfer of disulfide bonds by dithiol/disulfide exchange reactions to
CC the newly imported protein. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CMC4 family. {ECO:0000305}.
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DR EMBL; Z47815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006946; DAA10093.1; -; Genomic_DNA.
DR RefSeq; NP_878145.1; NM_001184524.1.
DR AlphaFoldDB; Q3E7A9; -.
DR SMR; Q3E7A9; -.
DR BioGRID; 37045; 29.
DR STRING; 4932.YMR194C-B; -.
DR MaxQB; Q3E7A9; -.
DR PaxDb; Q3E7A9; -.
DR PRIDE; Q3E7A9; -.
DR EnsemblFungi; YMR194C-B_mRNA; YMR194C-B; YMR194C-B.
DR GeneID; 1466503; -.
DR KEGG; sce:YMR194C-B; -.
DR SGD; S000028514; CMC4.
DR VEuPathDB; FungiDB:YMR194C-B; -.
DR eggNOG; ENOG502S7M4; Eukaryota.
DR GeneTree; ENSGT00390000012647; -.
DR HOGENOM; CLU_177210_0_0_1; -.
DR InParanoid; Q3E7A9; -.
DR OMA; CAIQNCI; -.
DR BioCyc; YEAST:G3O-33025-MON; -.
DR ChiTaRS; CMC4; yeast.
DR PRO; PR:Q3E7A9; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q3E7A9; protein.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR InterPro; IPR027179; MTCP1.
DR PANTHER; PTHR15590; PTHR15590; 1.
DR Pfam; PF08991; MTCP1; 1.
DR SUPFAM; SSF47072; SSF47072; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Mitochondrion; Reference proteome; Repeat.
FT CHAIN 1..73
FT /note="Cx9C motif-containing protein 4, mitochondrial"
FT /id="PRO_0000247790"
FT DOMAIN 2..44
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 5..15
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 26..36
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 5..36
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 15..26
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 73 AA; 8202 MW; 927DDAE583D52A26 CRC64;
MSNPCQKEAC AIQDCLLSHQ YDDAKCAKVI DQLYICCSKF YNDNGKDSRS PCCPLPSLLE
LKMKQRKLTP GDS
