CMCC2_CONPO
ID CMCC2_CONPO Reviewed; 65 AA.
AC D5L5Q8;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 25-MAY-2022, entry version 20.
DE RecName: Full=Conopeptide Vt3.2;
DE Flags: Precursor; Fragment;
OS Conus planorbis (Planorbis cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX NCBI_TaxID=97183;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=20307606; DOI=10.1016/j.peptides.2010.03.010;
RA Wu X.-C., Zhou M., Peng C., Shao X.-X., Guo Z.-Y., Chi C.-W.;
RT "Novel conopeptides in a form of disulfide-crosslinked dimer.";
RL Peptides 31:1001-1006(2010).
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is C-C.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
CC -!- CAUTION: The name Vt3.2 given by the authors is incorrect, since the
CC first number indicates a cysteine framework III which does not
CC correspond to this cysteine framework. {ECO:0000305|PubMed:20307606}.
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DR EMBL; GU784863; ADE35089.1; -; mRNA.
DR AlphaFoldDB; D5L5Q8; -.
DR ConoServer; 4060; Vt3.2 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Disulfide bond; Secreted;
KW Signal; Toxin.
FT SIGNAL <1..12
FT /evidence="ECO:0000255"
FT PROPEP 13..48
FT /evidence="ECO:0000250"
FT /id="PRO_0000397203"
FT PEPTIDE 52..64
FT /note="Conopeptide Vt3.2"
FT /id="PRO_0000397204"
FT MOD_RES 64
FT /note="Serine amide"
FT /evidence="ECO:0000255"
FT NON_TER 1
SQ SEQUENCE 65 AA; 7547 MW; 033CC2385F2713B3 CRC64;
LLFPLATLQL NADQPVERNA ENIQDLNPDK RFIFMPVPRR RGPYGSVHRR RGPYRRHGNC
FCPSG