CMCT_AMYLA
ID CMCT_AMYLA Reviewed; 486 AA.
AC Q04733;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Cephamycin export protein CmcT;
GN Name=cmcT;
OS Amycolatopsis lactamdurans (Nocardia lactamdurans).
OC Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC Amycolatopsis.
OX NCBI_TaxID=1913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LC411;
RX PubMed=8440253; DOI=10.1002/j.1460-2075.1993.tb05696.x;
RA Coque J.J.R., Liras P., Martin J.F.;
RT "Genes for a beta-lactamase, a penicillin-binding protein and a
RT transmembrane protein are clustered with the cephamycin biosynthetic genes
RT in Nocardia lactamdurans.";
RL EMBO J. 12:631-639(1993).
CC -!- FUNCTION: Involved in cephamycin export.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; Z13973; CAA78375.1; -; Genomic_DNA.
DR PIR; S36190; S36190.
DR AlphaFoldDB; Q04733; -.
DR SMR; Q04733; -.
DR TCDB; 2.A.1.3.8; the major facilitator superfamily (mfs).
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..486
FT /note="Cephamycin export protein CmcT"
FT /id="PRO_0000173319"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 486 AA; 49325 MW; B5F9B4712D4C793B CRC64;
MTSVRGASKT GRTSKTSTAT TALVLACTAH FLVVFDTSVI TVALPSVRAD LGFAPASLQW
VVNSYTLAFA GLLLFGGRLA DIHGHRRVFL GGLAVFTLTS LIGGLATSPA SLIAARAGQG
AGAAVLAPLA VTMLTTSFAE GPRRTRALTI STAVALVGGA SGNLLGGVFT EFLSWRSVLL
VNVPIGIPVL FLAARVLAGP RKRPWGRVRL DLPGAVLATA GLTLLTLGVS QTHEHGWGEA
AVAVPLAGGL LALLAFVVVE ARFAASPLIP PRLFGLPGVG WGNLAMLLAG ASQVPVWFFL
TLSMQHVLGY SAAQAGLGFV PHALVMLVVG LRVVPWLMRH VQARVLIAAG AAIGALGFWW
QSLLTPDSAY LGGILGPAVL ISIGGGLVGT PLARTVTSGV GPLDAGAASG LMNTTRQFGG
AFGLAVLLTV TGSGTSGSPA ELASHYGDAF VGIAVFMLAI AVLTPVLPAL ARSTPPGVIH
VSPVAR
