ID   CMGA_STRCA              Reviewed;         104 AA.
AC   P33716;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 2.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Chromogranin-A;
DE   Flags: Fragments;
GN   Name=CHGA;
OS   Struthio camelus (Common ostrich).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC   Struthio.
OX   NCBI_TaxID=8801;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=2188233; DOI=10.1016/0196-9781(90)90114-k;
RA   Lazure C., Paquet L., Litthauer D., Naude R.J., Oelofsen W., Chretien M.;
RT   "The ostrich pituitary contains a major peptide homologous to mammalian
RT   chromogranin A(1-76).";
RL   Peptides 11:79-87(1990).
CC   -!- FUNCTION: Chromogranin A probably has a paracrine role in the
CC       regulation of secretion or maturation.
CC   -!- SUBUNIT: Dimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Secreted.
CC   -!- SIMILARITY: Belongs to the chromogranin/secretogranin protein family.
CC       {ECO:0000305}.
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DR   PIR; A60417; A60417.
DR   AlphaFoldDB; P33716; -.
DR   SMR; P33716; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR   GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001819; Chromogranin_AB.
DR   InterPro; IPR018054; Chromogranin_CS.
DR   InterPro; IPR001990; Granin.
DR   PANTHER; PTHR10583; PTHR10583; 2.
DR   Pfam; PF01271; Granin; 2.
DR   PRINTS; PR00659; CHROMOGRANIN.
DR   PROSITE; PS00422; GRANINS_1; 1.
DR   PROSITE; PS00423; GRANINS_2; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..>104
FT                   /note="Chromogranin-A"
FT                   /id="PRO_0000144712"
FT   DISULFID        17..38
FT                   /evidence="ECO:0000255"
FT   NON_CONS        76..77
FT                   /evidence="ECO:0000305"
FT   NON_TER         104
SQ   SEQUENCE   104 AA;  11674 MW;  23957925F0BF4A28 CRC64;
     LPVTNNMNKG DTKVMKCIVE VISDTLSKPN PLPISEECLE TLRGDERIIS ILRHQNLLKE
     LQEIAVQGAN ERTQQQRRTE DQELESLAAI EAELESVAHS LQAL