CMIP_MOUSE
ID CMIP_MOUSE Reviewed; 773 AA.
AC Q9D486; Q69ZD2; Q8C3N2; Q8K148;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=C-Maf-inducing protein;
DE Short=c-Mip;
GN Name=Cmip; Synonyms=Kiaa1694;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-773 (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 249-773 (ISOFORM 1).
RC TISSUE=Pancreatic islet;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in T-cell signaling pathway. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FLNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IY22}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8IY22}. Note=Isoform 2 is translocated to the
CC nucleus and is specifically recruited during minimal change nephrotic
CC syndrome (MCNS). Detected in nuclear and cytoplasmic compartments
CC during MCNS relapse. Expressed in cytoplasm only during MCNS remission
CC and absent in normal patients. {ECO:0000250|UniProtKB:Q8IY22}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D486-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D486-2; Sequence=VSP_031113;
CC Name=3;
CC IsoId=Q9D486-3; Sequence=VSP_031114;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32512.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AK016712; BAB30392.1; -; mRNA.
DR EMBL; AK085367; BAC39432.1; -; mRNA.
DR EMBL; AC118207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC121116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028834; AAH28834.1; -; mRNA.
DR EMBL; AK173234; BAD32512.1; ALT_SEQ; mRNA.
DR CCDS; CCDS52680.1; -. [Q9D486-1]
DR CCDS; CCDS52681.1; -. [Q9D486-2]
DR RefSeq; NP_001156734.1; NM_001163262.1. [Q9D486-1]
DR RefSeq; NP_083217.1; NM_028941.1. [Q9D486-2]
DR AlphaFoldDB; Q9D486; -.
DR SMR; Q9D486; -.
DR IntAct; Q9D486; 1.
DR MINT; Q9D486; -.
DR STRING; 10090.ENSMUSP00000130264; -.
DR iPTMnet; Q9D486; -.
DR PhosphoSitePlus; Q9D486; -.
DR EPD; Q9D486; -.
DR MaxQB; Q9D486; -.
DR PaxDb; Q9D486; -.
DR PeptideAtlas; Q9D486; -.
DR PRIDE; Q9D486; -.
DR ProteomicsDB; 283316; -. [Q9D486-1]
DR ProteomicsDB; 283317; -. [Q9D486-2]
DR ProteomicsDB; 283318; -. [Q9D486-3]
DR Antibodypedia; 44799; 88 antibodies from 20 providers.
DR Ensembl; ENSMUST00000095172; ENSMUSP00000092795; ENSMUSG00000034390. [Q9D486-2]
DR Ensembl; ENSMUST00000166750; ENSMUSP00000130264; ENSMUSG00000034390. [Q9D486-1]
DR GeneID; 74440; -.
DR KEGG; mmu:74440; -.
DR UCSC; uc009noz.2; mouse. [Q9D486-1]
DR UCSC; uc009npa.2; mouse. [Q9D486-2]
DR CTD; 80790; -.
DR MGI; MGI:1921690; Cmip.
DR VEuPathDB; HostDB:ENSMUSG00000034390; -.
DR eggNOG; ENOG502QRSV; Eukaryota.
DR GeneTree; ENSGT00390000018220; -.
DR HOGENOM; CLU_018505_0_0_1; -.
DR InParanoid; Q9D486; -.
DR OMA; CEVHTAV; -.
DR OrthoDB; 355421at2759; -.
DR PhylomeDB; Q9D486; -.
DR TreeFam; TF328575; -.
DR BioGRID-ORCS; 74440; 21 hits in 74 CRISPR screens.
DR ChiTaRS; Cmip; mouse.
DR PRO; PR:Q9D486; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D486; protein.
DR Bgee; ENSMUSG00000034390; Expressed in entorhinal cortex and 254 other tissues.
DR Genevisible; Q9D486; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Leucine-rich repeat; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..773
FT /note="C-Maf-inducing protein"
FT /id="PRO_0000317629"
FT DOMAIN 54..163
FT /note="PH"
FT REPEAT 663..686
FT /note="LRR 1"
FT REPEAT 687..707
FT /note="LRR 2"
FT REPEAT 712..732
FT /note="LRR 3"
FT REPEAT 736..756
FT /note="LRR 4"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 349
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IY22"
FT MOD_RES 377
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IY22"
FT MOD_RES 382
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IY22"
FT MOD_RES 660
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IY22"
FT VAR_SEQ 1..100
FT /note="MDVTSSSGGGDPRQIEETKPLLGSDVSGPEGTKVMGAVPCRRALLLCNGMRY
FT KLLQEGDIQVCVIRHPRTFLSKILTSKFLRRWEPHHLTLADNSLASAT -> MKTFGPG
FT DEHPE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031113"
FT VAR_SEQ 486..773
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031114"
FT CONFLICT 138
FT /note="T -> A (in Ref. 2; BAB30392)"
FT /evidence="ECO:0000305"
FT CONFLICT 702
FT /note="G -> A (in Ref. 2; BAB30392)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 773 AA; 86259 MW; 1DCCF418339E552C CRC64;
MDVTSSSGGG DPRQIEETKP LLGSDVSGPE GTKVMGAVPC RRALLLCNGM RYKLLQEGDI
QVCVIRHPRT FLSKILTSKF LRRWEPHHLT LADNSLASAT PSGYMENSVS YSAIEDVQPL
SWENAPKYCL QLTIPGGTVL LQAANSYLRD QWFHSLQWKK KIYKYKKVLS NPSRWEVVLK
EIRTLVDMAL TSPLQDDSIN QAPLEIVSKL LSENTNLTTQ EHENIIVAIA PLLENNHPPP
DLCEFFCKHC RERPRSMVVI EVFTPVVQRI LKHNMDFGKC PRLRLFTQEY ILALNELNAG
MEVVKKFIQS MHGPTGHCPH PRVLPNLVAV CLAAIYSCYE EFINSRDNSP SLKEIRNGCQ
QPCDRKPTLP LRLLHPSPDL VSQEATLSEP RLKSVVVASS EVHVEVERTS TAKPALTAST
GNDSEPNLID CLMVSPACGT MSIELGPQAG RTLGCHVEIL KLLSDYDDWR PSLASLLQPI
PFPKEALAHE KFTKELKYVI QRFAEDPRQE VHSCLLSVRA GKDGWFQLYS PGGVACDDDG
ELFASMVHIL MGSCYKTKKF LLSLAENKLG PCMLLALRGN QTMAEILCLM LEYNIIDNND
TQLQIISTLE STDVGKRMYE QLCDRQRELK ELQRKGGPTR LTLPSKSTDA DLARLLSSGS
FGNLENLSLA FTNVTSACAE HLIKLPSLKQ LNLWSTQFGD AGLRLLSEHL TMLQVLNLCE
TPVTDAGLLA LSSMKSLCSL NMNSTKLSAD TYEDLKAKLP NLKEVDVRYT EAW
