CML43_ARATH
ID CML43_ARATH Reviewed; 181 AA.
AC Q9FI19; Q42141;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Probable calcium-binding protein CML43;
DE AltName: Full=Calmodulin-like protein 43;
GN Name=CML43; OrderedLocusNames=At5g44460; ORFNames=MFC16.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-181.
RC STRAIN=cv. Columbia;
RX PubMed=8281187; DOI=10.1046/j.1365-313x.1993.04061051.x;
RA Hoefte H., Desprez T., Amselem J., Chiapello H., Rouze P., Caboche M.,
RA Moisan A., Jourjon M.-F., Charpenteau J.-L., Berthomieu P., Guerrier D.,
RA Giraudat J., Quigley F., Thomas F., Yu D.-Y., Mache R., Raynal M.,
RA Cooke R., Grellet F., Delseny M., Parmentier Y., de Marcillac G., Gigot C.,
RA Fleck J., Philipps G., Axelos M., Bardet C., Tremousaygue D., Lescure B.;
RT "An inventory of 1152 expressed sequence tags obtained by partial
RT sequencing of cDNAs from Arabidopsis thaliana.";
RL Plant J. 4:1051-1061(1993).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX DOI=10.1046/j.1469-8137.2003.00845.x;
RA McCormack E., Braam J.;
RT "Calmodulins and related potential calcium sensors of Arabidopsis.";
RL New Phytol. 159:585-598(2003).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16240180; DOI=10.1007/s11103-005-8395-x;
RA Chiasson D., Ekengren S.K., Martin G.B., Dobney S.L., Snedden W.A.;
RT "Calmodulin-like proteins from Arabidopsis and tomato are involved in host
RT defense against Pseudomonas syringae pv. tomato.";
RL Plant Mol. Biol. 58:887-897(2005).
CC -!- FUNCTION: Calcium-binding protein that may mediate calcium-dependent
CC signal during plant defense response. {ECO:0000269|PubMed:16240180}.
CC -!- TISSUE SPECIFICITY: Expressed specifically in roots.
CC {ECO:0000269|PubMed:16240180}.
CC -!- INDUCTION: In leaves by infection with the bacterial pathogen
CC P.syringae. {ECO:0000269|PubMed:16240180}.
CC -!- CAUTION: Although assigned as a calmodulin family member by Ref.5, it
CC only contains EF-hand domains. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA81405.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB017065; BAB09153.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95111.1; -; Genomic_DNA.
DR EMBL; BT010849; AAR24216.1; -; mRNA.
DR EMBL; BT020593; AAW80866.1; -; mRNA.
DR EMBL; Z26706; CAA81405.1; ALT_FRAME; mRNA.
DR RefSeq; NP_199259.1; NM_123813.4.
DR AlphaFoldDB; Q9FI19; -.
DR SMR; Q9FI19; -.
DR STRING; 3702.AT5G44460.1; -.
DR iPTMnet; Q9FI19; -.
DR PaxDb; Q9FI19; -.
DR PRIDE; Q9FI19; -.
DR ProteomicsDB; 241081; -.
DR EnsemblPlants; AT5G44460.1; AT5G44460.1; AT5G44460.
DR GeneID; 834473; -.
DR Gramene; AT5G44460.1; AT5G44460.1; AT5G44460.
DR KEGG; ath:AT5G44460; -.
DR Araport; AT5G44460; -.
DR TAIR; locus:2163381; AT5G44460.
DR eggNOG; KOG0027; Eukaryota.
DR HOGENOM; CLU_061288_20_3_1; -.
DR InParanoid; Q9FI19; -.
DR OMA; GEGSCCD; -.
DR OrthoDB; 1340191at2759; -.
DR PhylomeDB; Q9FI19; -.
DR PRO; PR:Q9FI19; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FI19; baseline and differential.
DR Genevisible; Q9FI19; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0005509; F:calcium ion binding; IDA:TAIR.
DR GO; GO:0061891; F:calcium ion sensor activity; IDA:TAIR.
DR GO; GO:0051592; P:response to calcium ion; IDA:TAIR.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13405; EF-hand_6; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..181
FT /note="Probable calcium-binding protein CML43"
FT /id="PRO_0000342966"
FT DOMAIN 24..59
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 107..142
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 145..180
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 37
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 39
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 41
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 48
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 120
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 122
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 124
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 131
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 158
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 160
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 162
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 164
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 169
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 181 AA; 20254 MW; 7DC8F0E097D57962 CRC64;
MEINNEKKKL SRQSSSFRLR SPSLNALRLH RVFDLFDKNN DGFITVEELS QALSRLGLDA
DFSDLKSTVD SFIKPDKTGL RFDDFAALHK TLDESFFGGE GSCCDGSPES DLEEAFNVFD
EDGDGFISAV ELQKVLKKLG LPEAGEIEQV EKMIVSVDSN HDGRVDFFEF KNMMQTVVVP
S
