CML45_ARATH
ID CML45_ARATH Reviewed; 194 AA.
AC Q9MBG5;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Probable calcium-binding protein CML45 {ECO:0000305};
DE AltName: Full=Calmodulin-like protein 45 {ECO:0000303|Ref.4};
GN Name=CML45 {ECO:0000303|Ref.4}; OrderedLocusNames=At3g29000;
GN ORFNames=K5K13.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX DOI=10.1046/j.1469-8137.2003.00845.x;
RA McCormack E., Braam J.;
RT "Calmodulins and related potential calcium sensors of Arabidopsis.";
RL New Phytol. 159:585-598(2003).
CC -!- FUNCTION: Potential calcium sensor. {ECO:0000250}.
CC -!- CAUTION: Although assigned as a calmodulin family member by Ref.4, it
CC only contains EF-hand domains. {ECO:0000305}.
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DR EMBL; AB025615; BAA95753.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77519.1; -; Genomic_DNA.
DR EMBL; BX823042; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_189542.1; NM_113821.3.
DR AlphaFoldDB; Q9MBG5; -.
DR SMR; Q9MBG5; -.
DR BioGRID; 7869; 1.
DR STRING; 3702.AT3G29000.1; -.
DR PaxDb; Q9MBG5; -.
DR PRIDE; Q9MBG5; -.
DR DNASU; 822540; -.
DR EnsemblPlants; AT3G29000.1; AT3G29000.1; AT3G29000.
DR GeneID; 822540; -.
DR Gramene; AT3G29000.1; AT3G29000.1; AT3G29000.
DR KEGG; ath:AT3G29000; -.
DR Araport; AT3G29000; -.
DR TAIR; locus:2087002; AT3G29000.
DR eggNOG; KOG0027; Eukaryota.
DR HOGENOM; CLU_061288_11_0_1; -.
DR InParanoid; Q9MBG5; -.
DR OMA; FMESSFC; -.
DR OrthoDB; 1421213at2759; -.
DR PhylomeDB; Q9MBG5; -.
DR PRO; PR:Q9MBG5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9MBG5; baseline and differential.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 3.
DR PROSITE; PS00303; S100_CABP; 1.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..194
FT /note="Probable calcium-binding protein CML45"
FT /id="PRO_0000342956"
FT DOMAIN 76..98
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 122..157
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 160..194
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 52..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..81
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 135
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 137
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 139
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 146
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 173
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 175
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 177
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 179
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 184
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 194 AA; 22696 MW; 189312273323F6BA CRC64;
MESKSSSSSL PLFALFNFFL ISFCRWVSST RIFLSRFVPL LQHHQRVFDK KNNKDQQETL
TKQEDDDDDD DDDDDDDDDD IDISREEAEM VMRSLGLFYN DDQLQEQYSA KEVSSLFEEK
EASLEEVKQA FDVFDENKDG FIDAIELQRV LTILGFKQGS YLDNCLVMIR SLDGNKDGKI
DFNEFVKFME TSFY
