CML46_ARATH
ID CML46_ARATH Reviewed; 204 AA.
AC Q93Z27; Q9FK94;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Probable calcium-binding protein CML46 {ECO:0000305};
DE AltName: Full=Calmodulin-like protein 46 {ECO:0000303|Ref.4};
GN Name=CML46 {ECO:0000303|Ref.4}; OrderedLocusNames=At5g39670;
GN ORFNames=MIJ24.140;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX DOI=10.1046/j.1469-8137.2003.00845.x;
RA McCormack E., Braam J.;
RT "Calmodulins and related potential calcium sensors of Arabidopsis.";
RL New Phytol. 159:585-598(2003).
CC -!- FUNCTION: Potential calcium sensor. {ECO:0000250}.
CC -!- INTERACTION:
CC Q93Z27; P25854: CAM4; NbExp=2; IntAct=EBI-1235938, EBI-1235664;
CC -!- CAUTION: Although assigned as a calmodulin family member by Ref.4, it
CC only contains EF-hand domains. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB08899.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB012243; BAB08899.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002688; AED94462.1; -; Genomic_DNA.
DR EMBL; AY058192; AAL25605.1; -; mRNA.
DR EMBL; AY098977; AAM19987.1; -; mRNA.
DR RefSeq; NP_568568.1; NM_123329.2.
DR AlphaFoldDB; Q93Z27; -.
DR SMR; Q93Z27; -.
DR BioGRID; 19214; 6.
DR IntAct; Q93Z27; 7.
DR STRING; 3702.AT5G39670.1; -.
DR PaxDb; Q93Z27; -.
DR PRIDE; Q93Z27; -.
DR ProteomicsDB; 241084; -.
DR EnsemblPlants; AT5G39670.1; AT5G39670.1; AT5G39670.
DR GeneID; 833963; -.
DR Gramene; AT5G39670.1; AT5G39670.1; AT5G39670.
DR KEGG; ath:AT5G39670; -.
DR Araport; AT5G39670; -.
DR TAIR; locus:2164870; AT5G39670.
DR eggNOG; KOG0027; Eukaryota.
DR HOGENOM; CLU_061288_11_0_1; -.
DR InParanoid; Q93Z27; -.
DR OMA; IKHEEYR; -.
DR OrthoDB; 1421213at2759; -.
DR PhylomeDB; Q93Z27; -.
DR PRO; PR:Q93Z27; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q93Z27; baseline and differential.
DR Genevisible; Q93Z27; AT.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:1900425; P:negative regulation of defense response to bacterium; IMP:TAIR.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 1: Evidence at protein level;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..204
FT /note="Probable calcium-binding protein CML46"
FT /id="PRO_0000342968"
FT DOMAIN 72..106
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 132..167
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 170..204
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 145
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 147
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 149
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 156
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 204 AA; 23834 MW; B21A76FCEFD70DB6 CRC64;
MTENQLYSFI TMKSSLSKCK QSSSLSFPLF GLINFFLIGF FRWVSFAQLF FSRFWPLVQH
QQCVSEKKSK DLEFQTSIKH EEYRDDDDDG LCREDVGMVM KSLGLSTDQE NEGLQKQYSS
KEVSNLFEEK EPSLEEVKQA FDVFDENRDG FIDPIDLQRV LTILGLKQGS NLENCRRMIR
SFDGSKDGRI DFYGFVKFME NNFC
