CML48_ARATH
ID CML48_ARATH Reviewed; 228 AA.
AC Q9ZQH1; A2RVT7; Q0WPF4;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Probable calcium-binding protein CML48;
DE AltName: Full=Calmodulin-like protein 48;
GN Name=CML48; OrderedLocusNames=At2g27480; ORFNames=F10A12.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-228.
RC STRAIN=cv. Columbia;
RA Kim C.J., Bautista V.R., Chen H., De Los Reyes C., Wu S.Y., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX DOI=10.1046/j.1469-8137.2003.00845.x;
RA McCormack E., Braam J.;
RT "Calmodulins and related potential calcium sensors of Arabidopsis.";
RL New Phytol. 159:585-598(2003).
CC -!- FUNCTION: Potential calcium sensor. {ECO:0000250}.
CC -!- CAUTION: Although assigned as a calmodulin family member by Ref.5, it
CC only contains EF-hand domains. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD15600.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF00995.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC006232; AAD15600.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08001.1; -; Genomic_DNA.
DR EMBL; AK229120; BAF00995.1; ALT_FRAME; mRNA.
DR EMBL; BT030078; ABN04816.1; -; mRNA.
DR PIR; D84673; D84673.
DR RefSeq; NP_180317.3; NM_128308.6.
DR AlphaFoldDB; Q9ZQH1; -.
DR SMR; Q9ZQH1; -.
DR BioGRID; 2645; 1.
DR IntAct; Q9ZQH1; 1.
DR STRING; 3702.AT2G27480.1; -.
DR PaxDb; Q9ZQH1; -.
DR PRIDE; Q9ZQH1; -.
DR EnsemblPlants; AT2G27480.1; AT2G27480.1; AT2G27480.
DR GeneID; 817293; -.
DR Gramene; AT2G27480.1; AT2G27480.1; AT2G27480.
DR KEGG; ath:AT2G27480; -.
DR Araport; AT2G27480; -.
DR TAIR; locus:2038653; AT2G27480.
DR eggNOG; KOG0037; Eukaryota.
DR HOGENOM; CLU_051357_3_1_1; -.
DR InParanoid; Q9ZQH1; -.
DR OMA; DSMWTYF; -.
DR OrthoDB; 1330600at2759; -.
DR PhylomeDB; Q9ZQH1; -.
DR PRO; PR:Q9ZQH1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZQH1; baseline and differential.
DR Genevisible; Q9ZQH1; AT.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR044590; CML48/49/50.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR46824; PTHR46824; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..228
FT /note="Probable calcium-binding protein CML48"
FT /id="PRO_0000342971"
FT DOMAIN 52..87
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 121..156
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 65
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 67
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 69
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 76
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 228 AA; 26130 MW; 1CEAB58E2A8F7ABC CRC64;
MSYSNAYAPS APELPESFVQ QQHDGESRYT YAYPSYQPTQ QFSSYSGMFS PETHPEIVRS
FESADRNRSG FLEESELRQA LSLSGYDGIS NRTIRLLLFI YKIPVDSLLR LGPKEYVELW
NCLAQWRAIF NRYDRDRSGK MNSTQLRDAF YNLGCVLPTS VHQLIVSQFD DGTGKTVDLC
FDSFLECGMI VKGLTEKFRE NDPGYTGYAT LSYDVFMLMV IPFIATYD
