CMLD_STRVP
ID CMLD_STRVP Reviewed; 103 AA.
AC F2RB77;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 43.
DE RecName: Full=4-amino-4-deoxychorismate mutase {ECO:0000305};
DE Short=ADC mutase {ECO:0000303|PubMed:11577160};
DE EC=5.4.99.67 {ECO:0000305|PubMed:11577160};
GN Name=cmlD {ECO:0000303|PubMed:11577160};
GN OrderedLocusNames=SVEN_0918 {ECO:0000312|EMBL:CCA54205.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces.
OX NCBI_TaxID=953739;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD
RC 04745;
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Chandra G., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
RN [2]
RP FUNCTION, AND PATHWAY.
RC STRAIN=ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD
RC 04745;
RX PubMed=11577160; DOI=10.1099/00221287-147-10-2817;
RA He J., Magarvey N., Piraee M., Vining L.C.;
RT "The gene cluster for chloramphenicol biosynthesis in Streptomyces
RT venezuelae ISP5230 includes novel shikimate pathway homologues and a
RT monomodular non-ribosomal peptide synthetase gene.";
RL Microbiology 147:2817-2829(2001).
CC -!- FUNCTION: Involved in chloramphenicol biosynthesis. Probably catalyzes
CC the conversion of 4-amino-4-deoxychorismate to 4-amino-4-
CC deoxyprephenate. {ECO:0000305|PubMed:11577160}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate;
CC Xref=Rhea:RHEA:59376, ChEBI:CHEBI:58406, ChEBI:CHEBI:143070;
CC EC=5.4.99.67; Evidence={ECO:0000305|PubMed:11577160};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59377;
CC Evidence={ECO:0000305|PubMed:11577160};
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000305|PubMed:11577160}.
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DR EMBL; FR845719; CCA54205.1; -; Genomic_DNA.
DR RefSeq; WP_015032124.1; NZ_CP029197.1.
DR AlphaFoldDB; F2RB77; -.
DR SMR; F2RB77; -.
DR STRING; 953739.SVEN_0918; -.
DR EnsemblBacteria; CCA54205; CCA54205; SVEN_0918.
DR GeneID; 61485803; -.
DR KEGG; sve:SVEN_0918; -.
DR PATRIC; fig|953739.5.peg.2964; -.
DR eggNOG; COG1605; Bacteria.
DR HOGENOM; CLU_131518_1_1_11; -.
DR OMA; DIPMMQP; -.
DR BioCyc; MetaCyc:MON-20701; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0016835; F:carbon-oxygen lyase activity; IEA:InterPro.
DR GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0046417; P:chorismate metabolic process; IEA:InterPro.
DR GO; GO:0009697; P:salicylic acid biosynthetic process; IEA:InterPro.
DR Gene3D; 1.20.59.10; -; 1.
DR InterPro; IPR036263; Chorismate_II_sf.
DR InterPro; IPR036979; CM_dom_sf.
DR InterPro; IPR002701; CM_II_prokaryot.
DR InterPro; IPR008241; Isochorismate_pyruvate-lyase.
DR Pfam; PF01817; CM_2; 1.
DR SMART; SM00830; CM_2; 1.
DR SUPFAM; SSF48600; SSF48600; 1.
DR TIGRFAMs; TIGR01803; CM-like; 1.
DR PROSITE; PS51168; CHORISMATE_MUT_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis; Isomerase; Reference proteome.
FT CHAIN 1..103
FT /note="4-amino-4-deoxychorismate mutase"
FT /id="PRO_0000447222"
FT DOMAIN 1..92
FT /note="Chorismate mutase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00515"
SQ SEQUENCE 103 AA; 11889 MW; 4EA8199509E11E28 CRC64;
MTEQNELQRL RAELDALDGT LLDTVRRRID LGVRIARYKS RHGVPMMQPG RVSLVKDRAA
RYAADHGLDE SFLVNLYDVI ITEMCRVEDL VMSRESLTAE DRR
