ID   CMLO1_RAT               Reviewed;         221 AA.
AC   Q9QXT4;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Probable N-acetyltransferase CML1;
DE            EC=2.3.1.-;
DE   AltName: Full=Camello-like protein 1;
DE   AltName: Full=Camello-like protein 2;
GN   Name=Cml1 {ECO:0000250|UniProtKB:Q9JIZ0};
GN   Synonyms=Cml2 {ECO:0000312|RGD:621606};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAF22297.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAF22297.1};
RX   PubMed=11397015; DOI=10.1006/dbio.2001.0261;
RA   Popsueva A.E., Luchinskaya N.N., Ludwig A.V., Zinovjeva O.Y.,
RA   Poteryaev D.A., Feigelman M.M., Ponomarev M.B., Berekelya L.,
RA   Belyavsky A.V.;
RT   "Overexpression of camello, a member of a novel protein family, reduces
RT   blastomere adhesion and inhibits gastrulation in Xenopus laevis.";
RL   Dev. Biol. 234:483-496(2001).
RN   [2] {ECO:0000312|EMBL:AAH78836.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAH78836.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in regulation of gastrulation.
CC       {ECO:0000269|PubMed:11397015}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the camello family.
CC       {ECO:0000269|PubMed:11397015}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF185569; AAF22297.1; -; mRNA.
DR   EMBL; BC078836; AAH78836.1; -; mRNA.
DR   RefSeq; NP_067700.2; NM_021668.3.
DR   AlphaFoldDB; Q9QXT4; -.
DR   SMR; Q9QXT4; -.
DR   STRING; 10116.ENSRNOP00000021167; -.
DR   iPTMnet; Q9QXT4; -.
DR   PhosphoSitePlus; Q9QXT4; -.
DR   PaxDb; Q9QXT4; -.
DR   GeneID; 59300; -.
DR   KEGG; rno:59300; -.
DR   UCSC; RGD:621606; rat.
DR   CTD; 66116; -.
DR   RGD; 621606; Cml1.
DR   eggNOG; KOG3139; Eukaryota.
DR   InParanoid; Q9QXT4; -.
DR   OrthoDB; 1341682at2759; -.
DR   PhylomeDB; Q9QXT4; -.
DR   TreeFam; TF324687; -.
DR   PRO; PR:Q9QXT4; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IBA:GO_Central.
DR   GO; GO:0001702; P:gastrulation with mouth forming second; NAS:UniProtKB.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Developmental protein; Gastrulation; Membrane;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..221
FT                   /note="Probable N-acetyltransferase CML1"
FT                   /id="PRO_0000284687"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          69..219
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   221 AA;  24857 MW;  754357E00DFC079F CRC64;
     MAPYHIRQYQ DSDHKSVVDV FTKGMEEHIP STFRHMLMLP RTLLLLLGVP LALVLVSGSW
     LLAVVCIFFL LLLLRFLAGQ PWKEYVATCL RTDMADITKS YLNAHGSFWV AESGNQVVGI
     VAALPVKDPP SGRKQLQLFR LSVSSQHRGQ GIAKALVRTV LQFARDQGYT DVVLETSTLQ
     QGAMTLYLGM GFQKTGQRFL TMFWRLVGIR TIQLKYPFPS A