ID   CMLO6_RAT               Reviewed;         222 AA.
AC   Q9JIY6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Probable N-acetyltransferase CML6;
DE            EC=2.3.1.-;
DE   AltName: Full=Camello-like protein 1;
DE   AltName: Full=Camello-like protein 6;
GN   Name=Cml6; Synonyms=Cml1 {ECO:0000312|RGD:621605};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAF80487.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11397015; DOI=10.1006/dbio.2001.0261;
RA   Popsueva A.E., Luchinskaya N.N., Ludwig A.V., Zinovjeva O.Y.,
RA   Poteryaev D.A., Feigelman M.M., Ponomarev M.B., Berekelya L.,
RA   Belyavsky A.V.;
RT   "Overexpression of camello, a member of a novel protein family, reduces
RT   blastomere adhesion and inhibits gastrulation in Xenopus laevis.";
RL   Dev. Biol. 234:483-496(2001).
RN   [2] {ECO:0000312|EMBL:AAH81733.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAH81733.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in regulation of gastrulation.
CC       {ECO:0000269|PubMed:11397015}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the camello family.
CC       {ECO:0000269|PubMed:11397015}.
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DR   EMBL; AF163318; AAF80487.1; -; mRNA.
DR   EMBL; BC081733; AAH81733.1; -; mRNA.
DR   RefSeq; NP_598242.1; NM_133558.1.
DR   RefSeq; XP_008761325.1; XM_008763103.2.
DR   RefSeq; XP_008761326.1; XM_008763104.1.
DR   RefSeq; XP_008761327.1; XM_008763105.2.
DR   RefSeq; XP_008761328.1; XM_008763106.2.
DR   RefSeq; XP_008761329.1; XM_008763107.2.
DR   RefSeq; XP_017448499.1; XM_017593010.1.
DR   AlphaFoldDB; Q9JIY6; -.
DR   STRING; 10116.ENSRNOP00000021243; -.
DR   PaxDb; Q9JIY6; -.
DR   Ensembl; ENSRNOT00000088557; ENSRNOP00000068791; ENSRNOG00000056962.
DR   Ensembl; ENSRNOT00000096643; ENSRNOP00000078918; ENSRNOG00000056962.
DR   Ensembl; ENSRNOT00000116398; ENSRNOP00000077199; ENSRNOG00000056962.
DR   GeneID; 171084; -.
DR   KEGG; rno:171084; -.
DR   UCSC; RGD:621605; rat.
DR   CTD; 51471; -.
DR   RGD; 621605; RGD621605.
DR   VEuPathDB; HostDB:ENSRNOG00000063398; -.
DR   eggNOG; KOG3139; Eukaryota.
DR   GeneTree; ENSGT00950000182932; -.
DR   HOGENOM; CLU_013985_10_1_1; -.
DR   InParanoid; Q9JIY6; -.
DR   OMA; YEHMGYT; -.
DR   OrthoDB; 1341682at2759; -.
DR   PhylomeDB; Q9JIY6; -.
DR   TreeFam; TF324687; -.
DR   PRO; PR:Q9JIY6; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000015851; Expressed in kidney and 19 other tissues.
DR   Genevisible; Q9JIY6; RN.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:RGD.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISO:RGD.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0004468; F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; ISO:RGD.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IBA:GO_Central.
DR   GO; GO:0050435; P:amyloid-beta metabolic process; ISO:RGD.
DR   GO; GO:0001702; P:gastrulation with mouth forming second; NAS:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0018003; P:peptidyl-lysine N6-acetylation; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Developmental protein; Gastrulation; Membrane;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..222
FT                   /note="Probable N-acetyltransferase CML6"
FT                   /id="PRO_0000284696"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          62..217
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   222 AA;  24809 MW;  5104AFB38BBD7725 CRC64;
     MVSYHICEYQ DSDYKSVVDV FTKGAEEYIP STFRHLLLLP RTLLLLLGVS LALVLVSGSW
     LLAVVCIFFL LPFLWFLAGQ PWKNYVSKCL HTDMADITKS YLSDRGSGFW VAESGEQVVG
     TVGALPVKEP PSGRKQLQLF HLAVSSQHRG QGIAKALVRT VLQFARDQGY TDVVLETSTM
     QIGAVTLYLG MGFQKTGQYF PSMLWRLVGI RFVQLNYSFP SA