ID   CMLO_XENTR              Reviewed;         219 AA.
AC   Q66KL0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Probable N-acetyltransferase camello;
DE            EC=2.3.1.-;
GN   Name=cml {ECO:0000250|UniProtKB:Q9I8W5};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH80345.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH80345.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in regulation of gastrulation, possibly by
CC       controlled reduction of cell adhesion in the periblastopore region
CC       which is necessary for optimal cell motility.
CC       {ECO:0000250|UniProtKB:Q9I8W5}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the camello family.
CC       {ECO:0000250|UniProtKB:Q9I8W5}.
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DR   EMBL; BC080345; AAH80345.1; -; mRNA.
DR   RefSeq; NP_001008441.1; NM_001008441.1.
DR   AlphaFoldDB; Q66KL0; -.
DR   SMR; Q66KL0; -.
DR   STRING; 8364.ENSXETP00000056165; -.
DR   PaxDb; Q66KL0; -.
DR   DNASU; 493291; -.
DR   Ensembl; ENSXETT00000056165; ENSXETP00000056165; ENSXETG00000026706.
DR   GeneID; 493291; -.
DR   KEGG; xtr:493291; -.
DR   CTD; 493291; -.
DR   Xenbase; XB-GENE-5771028; nat8.4.
DR   eggNOG; KOG3139; Eukaryota.
DR   HOGENOM; CLU_013985_10_1_1; -.
DR   InParanoid; Q66KL0; -.
DR   OMA; VSIRKYK; -.
DR   OrthoDB; 1341682at2759; -.
DR   PhylomeDB; Q66KL0; -.
DR   TreeFam; TF324687; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026706; Expressed in neurula embryo and 5 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IBA:GO_Central.
DR   GO; GO:0001702; P:gastrulation with mouth forming second; ISS:UniProtKB.
DR   GO; GO:0007162; P:negative regulation of cell adhesion; ISS:UniProtKB.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Developmental protein; Gastrulation; Golgi apparatus;
KW   Membrane; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..219
FT                   /note="Probable N-acetyltransferase camello"
FT                   /id="PRO_0000284699"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          62..211
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   219 AA;  24866 MW;  8F598BF404FADC98 CRC64;
     MANVSIRKYK TSDYETARFL FAEGTKEHLP AACMYTLTTP RFYFITFVAF TSVFMGTGSY
     VLALTSLVAL LAAGWYGLYS EFHGLASRFL RKDMLDIEKS YMMSENACFW VAEIDGKVVG
     TVGAQPSTDA DDELLLQRIS VARDYRQLRI GTKLCQTVID FARQRGFNAV CLETANIQRA
     ATNLYERVGF KKSRVEILPS LVHQYTSFTV AYYRYNIKS