ID   CMLR_STRLI              Reviewed;         392 AA.
AC   P31141;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Chloramphenicol resistance protein;
GN   Name=cmlR;
OS   Streptomyces lividans.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=66 / 1326;
RX   PubMed=1779766; DOI=10.1111/j.1365-2958.1991.tb01987.x;
RA   Dittrich W., Betzler M., Schrempf H.;
RT   "An amplifiable and deletable chloramphenicol-resistance determinant of
RT   Streptomyces lividans 1326 encodes a putative transmembrane protein.";
RL   Mol. Microbiol. 5:2789-2797(1991).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; X59968; CAA42594.1; -; Genomic_DNA.
DR   PIR; S18593; S18593.
DR   AlphaFoldDB; P31141; -.
DR   SMR; P31141; -.
DR   TCDB; 2.A.1.2.32; the major facilitator superfamily (mfs).
DR   KEGG; ag:CAA42594; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..392
FT                   /note="Chloramphenicol resistance protein"
FT                   /id="PRO_0000173321"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   392 AA;  38855 MW;  8FE14E3563AA864E CRC64;
     MPLPLYLLAV AVCAMGTSEF MLAGLVPDIA SDLGVTVGTA GTLTSAFATG MIVGAPLVAA
     LARTWPRRSS LLGFILAFAA AHAVGAGTTS FPVLVACRVV AALANAGFLA VALTTAAALV
     PADKQGRALA VLLSGTTVAT VAGVPGGSLL GTWLGWRATF WAVAVCCLPA AFGVLKAIPA
     GRATAAATGG PPLRVELAAL KTPRLLLAML LGALVNAATF ASFTFLAPVV TDTAGLGDLW
     ISVALVLFGA GSFAGVTVAG RLSDRRPAQV LAVAGPLLLV GWPALAMLAD RPVALLTLVF
     VQGALSFALG STLITRVLYE AAGAPTMAGS YATAALNVGA AAGPLVAATT LGHTTGNLGP
     LWASGLLVAV ALLVAFPFRT VITTAAPADA TR