ID   CML_ECOLX               Reviewed;         302 AA.
AC   P12056;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Chloramphenicol resistance protein;
GN   Name=cml;
OS   Escherichia coli.
OG   Plasmid R26.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3011609; DOI=10.1016/0378-1119(86)90119-8;
RA   Dorman C.J., Foster T.J., Shaw W.V.;
RT   "Nucleotide sequence of the R26 chloramphenicol resistance determinant and
RT   identification of its gene product.";
RL   Gene 41:349-353(1986).
CC   -!- FUNCTION: This protein is thought to be a membrane-associated barrier
CC       of drug uptake.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
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DR   EMBL; M22614; AAA26079.1; -; Genomic_DNA.
DR   PIR; A25854; A25854.
DR   AlphaFoldDB; P12056; -.
DR   PRIDE; P12056; -.
DR   KEGG; ag:AAA26079; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   4: Predicted;
KW   Antibiotic resistance; Cell membrane; Membrane; Plasmid.
FT   CHAIN           1..302
FT                   /note="Chloramphenicol resistance protein"
FT                   /id="PRO_0000068564"
SQ   SEQUENCE   302 AA;  33390 MW;  4B4AD0F0B52D15B5 CRC64;
     MSFTAYSDPC WPWSRGRPIA RSARRHVAWV AGYLCVSRFG HDRCICRRGS FWPETRVQRV
     AGLQWSQLLL PVKCLNFWLY TLCYAAGMGS FFVFFSIAPG LMMGRPRCVS AWLQPAVRHS
     AIAMVFTARF MGSVIPKWGS PSVLRMGMGC LIAGAVLLAI TEIWALHRVR LYCSNVASGI
     GVATAVSVPM ALFEDSTMLL ERSRQSTSAW ACTARKHRNV DHFAVAAQRL GPCRVTVWTL
     ATVVLGLSCV SRVKGSRGQG EHDAGRATNV GKYIKSQSLR ECGKLSPNKC CSRPKTYAFR
     LG