ID   CMO1_CONMO              Reviewed;          13 AA.
AC   P84713;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Kappa-conotoxin Mo1659;
OS   Conus monile (Necklace cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX   NCBI_TaxID=351660;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT TYR-13.
RC   TISSUE=Venom {ECO:0000269|PubMed:15081394};
RX   PubMed=15081394; DOI=10.1016/j.bbrc.2004.03.100;
RA   Sudarslal S., Singaravadivelan G., Ramasamy P., Ananda K., Sarma S.P.,
RA   Sikdar S.K., Krishnan K.S., Balaram P.;
RT   "A novel 13 residue acyclic peptide from the marine snail, Conus monile,
RT   targets potassium channels.";
RL   Biochem. Biophys. Res. Commun. 317:682-688(2004).
CC   -!- FUNCTION: Inhibits non-inactivating voltage-gated potassium channels in
CC       rat dorsal root ganglion neurons. {ECO:0000269|PubMed:15081394}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15081394}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:15081394}.
CC   -!- MASS SPECTROMETRY: Mass=1659.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15081394};
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0019870; F:potassium channel inhibitor activity; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
DR   GO; GO:0044361; P:negative regulation of voltage-gated potassium channel activity in another organism; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..13
FT                   /note="Kappa-conotoxin Mo1659"
FT                   /id="PRO_0000044884"
FT   MOD_RES         13
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:15081394"
SQ   SEQUENCE   13 AA;  1660 MW;  26D0AFA7570A1B43 CRC64;
     FHGGSWYRFP WGY