ID   CMPA_SYNP6              Reviewed;         450 AA.
AC   Q5MZ56;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Bicarbonate-binding protein CmpA;
DE   Flags: Precursor;
GN   Name=cmpA; OrderedLocusNames=syc2474_d;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
CC   -!- FUNCTION: Part of the ABC transporter complex CmpABCD involved in
CC       bicarbonate transport. Binds bicarbonate with high affinity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CmpC and
CC       CmpD), a transmembrane protein (CmpB) and a solute-binding protein
CC       (CmpA). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- INDUCTION: By carbon dioxide-limited conditions, probably via CmpR.
CC       {ECO:0000250}.
CC   -!- PTM: Predicted to be exported by the Tat system. The position of the
CC       signal peptide cleavage has not been experimentally proven.
CC   -!- SIMILARITY: Belongs to the CmpA/NrtA family. {ECO:0000305}.
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DR   EMBL; AP008231; BAD80664.1; -; Genomic_DNA.
DR   RefSeq; WP_011244784.1; NC_006576.1.
DR   AlphaFoldDB; Q5MZ56; -.
DR   SMR; Q5MZ56; -.
DR   STRING; 269084.syc2474_d; -.
DR   PRIDE; Q5MZ56; -.
DR   EnsemblBacteria; BAD80664; BAD80664; syc2474_d.
DR   KEGG; syc:syc2474_d; -.
DR   eggNOG; COG0715; Bacteria.
DR   OMA; GGQWQMP; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd13553; PBP2_NrtA_CpmA_like; 1.
DR   InterPro; IPR044527; NrtA/CpmA_ABC-bd_dom.
DR   InterPro; IPR006311; TAT_signal.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Signal;
KW   Transport.
FT   SIGNAL          1..36
FT                   /note="Tat-type signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT   CHAIN           37..450
FT                   /note="Bicarbonate-binding protein CmpA"
FT                   /id="PRO_0000341963"
SQ   SEQUENCE   450 AA;  49094 MW;  D85685C14CBE30BE CRC64;
     MNEFQPVNRR QFLFTLGATA ASAILLKGCG NPPSSSGGGT SSTTQPTAAG ASDLEVKTIK
     LGYIPIFEAA PLIIGREKGF FAKYGLDVEV SKQASWAAAR DNVILGSAGG GIDGGQWQMP
     MPALLTEGAI SNGQKVPMYV LACLSTQGNG IAVSNQLKAQ NLGLKLAPNR DFILNYPQTS
     GRKFKASYTF PNANQDFWIR YWFAAGGIDP DKDIELLTVP SAETLQNMRN GTIDCFSTGD
     PWPSRIAKDD VGYQAALTGQ MWPYHPEEFL ALRADWVDKH PKATLALLMG LMEAQQWCDQ
     KANRAEMAKI LSGRNFFNVP VSILQPILEG QIKVGADGKD LNNFDAGPLF WKSPRGSVSY
     PYKGLTLWFL VESIRWGFNK QVLPDIAAAQ KLNDRVTRED LWQEAAKKLG VPAADIPTGS
     TRGTETFFDG ITYNPDSPQA YLQSLKIKRA