CMPR_SYNE7
ID CMPR_SYNE7 Reviewed; 323 AA.
AC Q9F1R2;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=HTH-type transcriptional activator CmpR;
GN Name=cmpR; OrderedLocusNames=Synpcc7942_1310;
OS Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS R2).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX NCBI_TaxID=1140;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION AS A TRANSCRIPTIONAL
RP REGULATOR.
RX PubMed=11222586; DOI=10.1128/jb.183.6.1891-1898.2001;
RA Omata T., Gohta S., Takahashi Y., Harano Y., Maeda S.;
RT "Involvement of a CbbR homolog in low CO2-induced activation of the
RT bicarbonate transporter operon in cyanobacteria.";
RL J. Bacteriol. 183:1891-1898(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7942 / FACHB-805;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Kyrpides N., Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Activates transcription of the cmpABCD operon under carbon
CC dioxide-limited conditions. {ECO:0000269|PubMed:11222586}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; AB047379; BAB18722.1; -; Genomic_DNA.
DR EMBL; CP000100; ABB57340.1; -; Genomic_DNA.
DR RefSeq; WP_011242557.1; NC_007604.1.
DR PDB; 5Z49; X-ray; 2.15 A; A/B=94-323.
DR PDBsum; 5Z49; -.
DR AlphaFoldDB; Q9F1R2; -.
DR SMR; Q9F1R2; -.
DR STRING; 1140.Synpcc7942_1310; -.
DR PRIDE; Q9F1R2; -.
DR EnsemblBacteria; ABB57340; ABB57340; Synpcc7942_1310.
DR KEGG; syf:Synpcc7942_1310; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_6_1_3; -.
DR OMA; FLRTYMY; -.
DR OrthoDB; 750230at2; -.
DR BioCyc; SYNEL:SYNPCC7942_1310-MON; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; Cytoplasm; DNA-binding; Transcription;
KW Transcription regulation.
FT CHAIN 1..323
FT /note="HTH-type transcriptional activator CmpR"
FT /id="PRO_0000341942"
FT DOMAIN 4..61
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 21..40
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT REGION 304..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 94..101
FT /evidence="ECO:0007829|PDB:5Z49"
FT HELIX 102..106
FT /evidence="ECO:0007829|PDB:5Z49"
FT HELIX 109..118
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 122..129
FT /evidence="ECO:0007829|PDB:5Z49"
FT HELIX 131..140
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 144..150
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 153..155
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 157..164
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 167..172
FT /evidence="ECO:0007829|PDB:5Z49"
FT HELIX 176..179
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 181..183
FT /evidence="ECO:0007829|PDB:5Z49"
FT HELIX 185..189
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 193..195
FT /evidence="ECO:0007829|PDB:5Z49"
FT HELIX 201..212
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 219..222
FT /evidence="ECO:0007829|PDB:5Z49"
FT HELIX 226..234
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 239..243
FT /evidence="ECO:0007829|PDB:5Z49"
FT HELIX 244..247
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 256..259
FT /evidence="ECO:0007829|PDB:5Z49"
FT STRAND 269..278
FT /evidence="ECO:0007829|PDB:5Z49"
FT HELIX 282..301
FT /evidence="ECO:0007829|PDB:5Z49"
SQ SEQUENCE 323 AA; 35776 MW; 91932129F43FD004 CRC64;
MKNLTLHQLK VFEAAARHSS FTRAAEELYL TQPTVSIQVK QLTKAVGLPL FEQIGKRLYL
TEAGRQLYKT TRQVFEQLEQ LDMTIADLQG MKQGQLRLAV ITTAKYFIPR LIGPFCQRYP
GINVSLKVTN HEGLINRIND NLDDLYVLSR PPSGFDITVQ PFLDNPLVVV GPASHPLANQ
RGISLERLAQ EPFILRERGS GTREATEQLF AAHNLNLNVK LDLGSNEAIK QAILGGLGLA
VLSYHTLTSA GATPELKMFE VEGFPIHRQW HAVYPAGKQL STVAATFLDY LLTESQRIAA
DIQIPESTTT DPELDAPQPV VGV