CMPR_SYNY3
ID CMPR_SYNY3 Reviewed; 304 AA.
AC Q55459;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=HTH-type transcriptional activator CmpR;
GN Name=cmpR; OrderedLocusNames=sll0030;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
RN [2]
RP FUNCTION, AND DNA-BINDING.
RX PubMed=11222586; DOI=10.1128/jb.183.6.1891-1898.2001;
RA Omata T., Gohta S., Takahashi Y., Harano Y., Maeda S.;
RT "Involvement of a CbbR homolog in low CO2-induced activation of the
RT bicarbonate transporter operon in cyanobacteria.";
RL J. Bacteriol. 183:1891-1898(2001).
CC -!- FUNCTION: Activates transcription of the cmpABCD operon under carbon
CC dioxide-limited conditions. Specifically binds to the cmpR-cmpA
CC intergenic region. {ECO:0000269|PubMed:11222586}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; BA000022; BAA10802.1; -; Genomic_DNA.
DR PIR; S75955; S75955.
DR AlphaFoldDB; Q55459; -.
DR SMR; Q55459; -.
DR STRING; 1148.1001315; -.
DR PaxDb; Q55459; -.
DR EnsemblBacteria; BAA10802; BAA10802; BAA10802.
DR KEGG; syn:sll0030; -.
DR eggNOG; COG0583; Bacteria.
DR InParanoid; Q55459; -.
DR OMA; FERYGKR; -.
DR PhylomeDB; Q55459; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..304
FT /note="HTH-type transcriptional activator CmpR"
FT /id="PRO_0000341943"
FT DOMAIN 1..61
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 21..40
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 304 AA; 34099 MW; 7964D82BC3D8A9BF CRC64;
MKNATLHQFE VFAAIARTGS FTKAAEELFL TQPTVSQQMK QLTKAIGVPL YEQIGRKIYL
TEAGQAVLDA SKNITSCLDQ LQEVIADLQG LKKGNLRLAT ITTGKYFVPR LLGEFRQQYP
GISISLQIGN RQQILERLAN NLDDLYFLGK PPSNLDINIR HFLENPLVVI ASRQHPLVKE
KKISLERLVN EPLIMRESGS GTRMAVEEFF SENRLKMNVE MEISSNEAIK QAVYGGLGIS
ILSLYSLALE GINGPLAVLD VEGFPLQKHW YIIYQKSKQL SIVAQTFLDY LFAHDEAVSI
AQIF
