ID   CMR1_ASHGO              Reviewed;         513 AA.
AC   Q75BS7;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN   OrderedLocusNames=ACR194C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; AE016816; AAS51420.1; -; Genomic_DNA.
DR   RefSeq; NP_983596.1; NM_208949.1.
DR   AlphaFoldDB; Q75BS7; -.
DR   SMR; Q75BS7; -.
DR   STRING; 33169.AAS51420; -.
DR   EnsemblFungi; AAS51420; AAS51420; AGOS_ACR194C.
DR   GeneID; 4619728; -.
DR   KEGG; ago:AGOS_ACR194C; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   InParanoid; Q75BS7; -.
DR   OMA; TVVRHNC; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..513
FT                   /note="DNA damage-binding protein CMR1"
FT                   /id="PRO_0000351096"
FT   REPEAT          183..224
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          237..277
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          329..369
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          386..425
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          438..477
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          478..513
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REGION          35..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  57793 MW;  6B92DD1938891760 CRC64;
     MTANSEFNKR RLENIKRNNE LLKKLNLAGI PARIRSEAGI EDHRKASGGA VKKKQGKAPV
     KREAKPAPIP TRRSRRLRGE AADVEGEAGA GSDTAQNVKQ EEEWKELKEA RVVGDIKLSD
     LIKSEDDGEL LEKFRRYADK SFSGGDFFEE LQRHQKPNPE VQRLREEMRL QQYDVFDPKE
     LAIVHERVTA LCFHPSQEKK LIVGGDTAGT VGLWNVADEN PDPEHPDSVP DITRFKLFSR
     NVSKIEVFPT DSSKILAASY DGALRSIDMQ SLKSDELLHF QNEHGDTLGI SDCQFSYDSP
     NVVMLTTLGG EFAQRDLRTK PDTMNIMRLS DKKIGCMAID PSRPYSVATA SLDRTLRIWD
     LRKTVAKPDW SQYEDYASHE VVSTYNSRLS VSAVSYAPID HTLVCNGYDN TVRLFNARAD
     LPSELQPDFT IQHNCKSGRW VSVLKARFKL NMDVFAIANM KRAIDIYTSR GEQLSHLETS
     TVPAVVSWHP MQNWIVGGNN SGKVFLFTDA PQE