ID   CMR1_ASPCL              Reviewed;         531 AA.
AC   A1CU75;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA damage-binding protein cmr1 {ECO:0000250|UniProtKB:Q12510};
GN   ORFNames=ACLA_085580;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; DS027060; EAW06862.1; -; Genomic_DNA.
DR   RefSeq; XP_001268288.1; XM_001268287.1.
DR   AlphaFoldDB; A1CU75; -.
DR   SMR; A1CU75; -.
DR   STRING; 5057.CADACLAP00007393; -.
DR   PRIDE; A1CU75; -.
DR   EnsemblFungi; EAW06862; EAW06862; ACLA_085580.
DR   GeneID; 4700440; -.
DR   KEGG; act:ACLA_085580; -.
DR   VEuPathDB; FungiDB:ACLA_085580; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   OMA; TVVRHNC; -.
DR   OrthoDB; 753973at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..531
FT                   /note="DNA damage-binding protein cmr1"
FT                   /id="PRO_0000351097"
FT   REPEAT          186..227
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          253..293
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          300..340
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          345..385
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          392..431
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          454..497
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          500..531
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          37..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   531 AA;  59012 MW;  703F582F773FC0DE CRC64;
     MGTDSTELSE FEKQRLANIA ERDALLKKLT LDAQSSGIFP PKLARSSPVS QTKPKKKPAP
     KKIKKEGEAP VARRMSSRLR GIAAESEVAK RKAEEHYEAV QQAERAKRVR KSDAFSFSEM
     LVSGQKLSAD GLIGVDVVTK GVAMPYQRTF GDEDIEKTAD KELKRLREEV SGLQLWEAWE
     PNRIKVTPER IYTMTFHPSE AKPLIFAGDK MGNLGVLDAS QERPVSSIKH EDGDEEEQED
     DDDPDPVLTT LKPHTRTISS MHIHPSKPTH LYTASYDSSI RELDLEKTTS VETYAPDSPS
     DDVPISGIDM AADDPNTLYW TTLDGAFGRY DTRASRRTAV ATWQLSEKKI GGFSLYPTHP
     HFFATASLDR TMRLWDLRKL SHDDPLPVGE HLSRLSVSHA AFNSAGQVAT SSYDDSLKIY
     DFGAKGIASW EQGHTLSDAE MKPDTVVRHN CQTGRWVTIL RPQWQANPQS HIQRFCIGNM
     NRFVDVYSSS GDQLAQLGGD GITAVPAVAV FHRSKNWIAG GTASGKICLW M