ID   CMR1_ASPFC              Reviewed;         528 AA.
AC   B0Y8S0;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=DNA damage-binding protein cmr1 {ECO:0000250|UniProtKB:Q12510};
GN   ORFNames=AFUB_078330;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS499599; EDP49801.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0Y8S0; -.
DR   EnsemblFungi; EDP49801; EDP49801; AFUB_078330.
DR   VEuPathDB; FungiDB:AFUB_078330; -.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   PhylomeDB; B0Y8S0; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Repeat; WD repeat.
FT   CHAIN           1..528
FT                   /note="DNA damage-binding protein cmr1"
FT                   /id="PRO_0000351098"
FT   REPEAT          185..226
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          250..290
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          297..337
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          342..382
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          389..428
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          451..494
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          497..528
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          32..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   528 AA;  58521 MW;  6B86383ACF9D62AE CRC64;
     MGADNELSEF EKQRLANIAE RDALLKKLSL DAQSSGLFPP KSARSSPGGQ TKPKKKPPPK
     KVKKEDEHPV PRRMSSRLRG LAADSEVAKR KADEQYEAAQ QAERAKRVRK SDAFSFSEML
     VSGQKLSGDS LIGVDVVTKG VAMPYQRTFG DEDIKKTTDK ELKALREEMS GLRLWEAWEP
     NRIKLTPERI YTMTFHPSEA KPLIFAGDKM GNLGVLDASQ EKPTSAVKQE DDEEDAEDDD
     PDPVLTTLKP HTRTISSLHI HPSKPTHLYS ASYDSSIREL DLEKTTSVEK YAPESTSDDI
     PISGIDMAPD DPNTLYWTTL DGAFGRYDTR ASRRSAVATW QLSEKKIGGF SLFPTHPHFF
     ATASLDRTMR LWDIRKLSHD DPVPVGEHVS RLSVSHAAFN SAGQIATSSY DDTLKIYDFG
     SKGIAAWEPG YTLSDAEMKP DTIVRHNCQT GRWVTILRPQ WQANPQSSIQ RFCIGNMNRF
     VDVYSSSGDQ LAQLGGDGIT AVPAVAVFHC STNWIAGGTA SGKICLWM