ID   CMR1_ASPOR              Reviewed;         522 AA.
AC   Q2UUT4;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=DNA damage-binding protein cmr1 {ECO:0000250|UniProtKB:Q12510};
GN   ORFNames=AO090009000186;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP007150; BAE54681.1; -; Genomic_DNA.
DR   RefSeq; XP_001816683.2; XM_001816631.2.
DR   AlphaFoldDB; Q2UUT4; -.
DR   SMR; Q2UUT4; -.
DR   STRING; 510516.Q2UUT4; -.
DR   EnsemblFungi; BAE54681; BAE54681; AO090009000186.
DR   GeneID; 5988613; -.
DR   KEGG; aor:AO090009000186; -.
DR   VEuPathDB; FungiDB:AO090009000186; -.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   OMA; TVVRHNC; -.
DR   Proteomes; UP000006564; Chromosome 1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..522
FT                   /note="DNA damage-binding protein cmr1"
FT                   /id="PRO_0000351100"
FT   REPEAT          182..223
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          244..284
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          294..331
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          336..376
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          381..422
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          445..488
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          491..522
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          34..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   522 AA;  58316 MW;  70B99870394A8616 CRC64;
     MGNEEISDFE KQRLANIAER DALLKQLSLN AQSVFTPTLP NRATGSQAKT KKKPAPKKVK
     KEEESPAPRR MSSRLRGIAA DSEVAKRKAE EQHQAYQEAE RAKRVRKSDS FSLNDIFVSG
     QKLSGDGLLG VDVVTKGVAV PYQRTFGDDD IKKTTDKELK ALRKEMSELQ LWEAWEPNRI
     KLTPERVYTM TFHPSETKPL IFAGDKMGHL GILDASQEKP TSVKQEDEDE EDDDPDPVLT
     TLKPHTRTIS SMVIHPSKPT HLYTASYDSS IREMDLDKTT SVERYAPDST SDDVPLSGLD
     MAADDPNTLY WTTLEGEFGR YDMRTPKQGS VAVWSLSEKK IGGFSLFPTH SHYFATASLD
     RTMRLWDIRK LSRREPVPVG EHQSRLSVSH AAFNSAGQVA TSSYDDSLKL YDFGAKGIAS
     WKPGHTLSDA EMKPDTVVRH NCQTGRWVTI LRPQWQINPQ SHIQRFCIGN MNRFVDVYSS
     SGDQLAQLGG DGITAVPAVA VFHRSKNWIA GGTASGKICL WM